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I really did go back down to 4.5 because of the mood thing. I had suffered severe PMS depression a couple of years ago and it came back hard on the 6mg month so I suspected the LDN. Symptom wise, I'm better than without ldn, it makes the celebrex work, I can't live without celebrex now though. I'm still on a good/bad roller coaster with symptoms of AS but the lows aren't as low with ldn. MY current line of thinking is that I am young and relatively new to AS and so I think I may try another biologic soon. I'm afraid I have damage and fusing going on behind the scenes.
