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Now this guy is certainly no Dr and has questionable motives and products but he notes that when you take folate, one must take b12 and vice versa. I haven't found any other reputable sources discussing that but it's something worth looking into. I've had a bottle of methyl folate(400 mgcaps) and methyl cobalamin(5mg tabs) sitting around for a few months unused. I looked at perfect health diet and his rec. dose amounts which are miniscule in comparison to Dave Asprey's. I decided to not use them until I found more concrete evidence.