I think it is a combination of things. The feelings of hopelessness, the never ending pain,disability, fatigue and all the different meds we take.

My lowest point was when my UC got to the point that I was completely housebound. I couldn't leave the house without mapping all the possible bathroom stops and had an emergency pack of clean clothes, a plastic bag and at one time, diapers. When I finally got all my meds to kick in, my mood improved greatly.

I don't think it is possible to not be affected by all this.
Donna

Donna
Cherish your yesterdays,
Dream your tomorrows,
But live your todays.
Do the very best you can
leave the rest to God.
God Bless,