Unfortunately there is not a single drug or medical treatment out there that does not have some side effect or risk. The human body is so unique and we are all so slight different there will never be a completely safe drug. If we hold that standard then we basically can offer very few treatments for disease. Human suffering would increase greatly under that scenario.
we all make decisions based on our willingness to take the risk and the benefits we are looking for. tough calls indeed.
This was also a case of high dose bis drugs used to fight cancer. Risks are even greater there but some of these cancer patients had few other options back then.