Kickas.org Forums Ankylosing Spondylitis General Discussion #1 AS Web Support Group How many were Hla-b27 and CRP negative when diagno

How many of you were Hla-b27 and c reactive protein negative and were still diagnosed with AS ?? I just got my latest blood work results back from my GP. everything is " normal " as usual. I have had these tests a few times over the years always the same result. I have a appointment to see the rheumatologist in a month ( This is the first time for me at the rhumy ) I have had these symptoms for years, and have been getting the run around like Nothing is really wrong because it's not showing up in the blood test. Now that this has been going on for so long (Like 10 years) he is finally sending me to the Rhumy. I am worried that the rheumatologist is just going to broom me out the door like the rest because of the normal blood work!

I am being treated and I have all negative blood work and I'm b27 negative. My dr thought I had as after a xray showed sacroiliac scarring, but when the mri did not show the scarring, he changed the diagnosis to ra. I think I have as by itself or as and ra, but not just ra. I'm currently on sulfasalzine and mobic for meds. I'm also going to a llmd soon to rule out lyme, but I really doubt it's lyme due to the area I live in and the fact that I spent a lot of time indoors before i began having symptoms.



Good luck.

I'm negative and proud of it!
Seriously the 90% positive ratio is so yesterday
again it is for those who are northern European (mostly Nordic)and male. And now, even those ratios are changing.
Remember it used to be a "male" disease with a ratio of about 9-1
now, it's around 3-1 or even 2-1 male to female being diagnosed.

You will probably have to deal with people (either doctors or those with AS) who think that you HAVE to be positive or else it isn't "really" AS. there are a few on this site who come across as having this mindset-- ignore them.

I am negative as far as the HLA, but did have an elevated CRP. I will say for me the MRI really didn't pick up much. It was a pelvic cat scan that showed the changes. Maybe ask for that?

HLAB27 negative.

CRP and sed rate on the high side of normal, but still considered normal by most of the doctors. My current doctors now think elevated is elevated even if its still within "normal".

I wasn't diagnosed based on blood work or on imaging scans.

Rather I was diagnosed based on symptoms:

joint and enthesis inflammation, stomach and ileum inflammation, a little psoriasis, dry eyes, mouth inflammation, leg / foot rashes.

My CRP level was very high and I had erosion of SI joints so the diagnosis was pretty definite. I am HLA negative though, but I don't think it changes the treatment or even the prognosis.

I do not know if I am Hla-B27 positive. I have never been serum tested for it. I have elevated CRP levels, B12 and D deficiency. Painful hips. Inability to bend over and unable to bend backwards. Constant aching in my hips causes a lot of pain when standing up. Hips ache badly at night.

New doctor wants me to come in ASAP. X-rays have been read. Receptionist said they have been calling me all week long and sent letters to me marked URGENT. I never received a single call or letter from them.

Have appointment tomorrow at 2:40 to see the Dr.

I was HLA-B27 neg + CRP/sed rate normal. X-rays + MRI were normal (though I learned later they didn't give me gadolinium in order to see inflammation!!) Then I guess I would have had a positive MRI because my SI joints hurt like a [*bleep*].

I was then diagnosed only from my symptoms. I began Humira this week, since I have been having a huge flare that won't go away! My rheumy is super nice and so well informed of all the ways AS can hit differently on people. She diagnosed me within a month.

It's been a year since my diagnosis, and BOOM syndesmophytes on my cervical X-ray. She was so right!

Do syndesmophytes always lead to fusion?

Thanks for all the info, I just want to figure out what is wrong with me! Tired of being sick and tired and in pain. It's been about 10 years that this has been coming and going. The older I get the harder it is to push myself. I probably should have been refered to a rhumy years ago. I do see that most people take years to get diagnosed