Kickas.org Forums Treatments, Drugs and Alternatives NSD and diet-related; yeast intolerance

I'm a 32-yo guy with mild UC for 12 years and AS/uveitis for 5 years. With all the talk of autoimmune being linked to diet I was sure I had food sensitivities.

This year I took a IgE food intolerance test (http://rmalab.com/medical-laboratory-tests/allergy/igg-food-allergy). To my surprise, the results came up "no intolerance" on all foods except for Yeast which was ranked "high intolerance", and Dairy, ranked "mild intolerance".

Does this mean I have to avoid foods with yeast? (breads, etc.) Or a full-on Candida diet? It's also not clear to me whether this has anything to do with AS or is a separate unrelated issue.

Anyone with yeast or other food intolerance related to AS, I would really appreciate your advice in interpreting these results.

Didier

Hi

On average IBD and Spondy patients have increased levels of antibodies to bakers/brewers yeast (Saccharomyces cerevisiae) compared to the general population. Here is a recent paper on ASCA and spondyloarthritis - http://www.ncbi.nlm.nih.gov/pubmed/21305298

Some IBD researchers think that yeast antibodies might be a marker for gut inflammation: "Our investigations started with the development of the ASCA test (detection of anti-S. cerevisiae (mannan) antibodies), allowing large scale serological studies on a chemically-defined yeast antigen. This test revealed that ASCA were potent serological markers, present in 60% of CD patients and 20% of their healthy relatives (HR) compared with only 7% of control subjects." - http://www.ncbi.nlm.nih.gov/pubmed/20203505

"It is conceivable that ASCA positivity correlates with the (auto-) immune inflammation of small intestines and it is a specific marker of Crohn's disease." - http://www.ncbi.nlm.nih.gov/pubmed/14562398

There is some evidence that the ASCA antibodies might be due to candida albicans: "ASCAs could result from an altered immune response to C. albicans. In CD, a subsequent alteration in sensing C. albicans colonization could occur with disease onset." - http://www.ncbi.nlm.nih.gov/pubmed/19471251

Clinical and experimental data have revealed that the major oligomannose epitopes supporting ASCA are expressed by C. albicans in human tissues, suggesting that C. albicans is the immunogen for ASCA. This putative link has been reinforced by the recent demonstration that novel serological markers of CD (ALCA and ACCA), consisting of antibodies against synthetic disaccharide fragments of chitin and glucan (components of the C. albicans cell wall), are also generated during C. albicans infection. Mycological investigation of families with multiple cases of CD has shown that CD patients and their HR are more likely to be colonized with C. albicans than control families. In HR, C. albicans colonization correlated with ASCA levels whereas disease onset was associated with ASCA stability and independence from C. albicans intestinal load." - http://www.ncbi.nlm.nih.gov/pubmed/20203505

"In a series of studies following the original description of ASCA, we demonstrated that in contrast with the iniquitous yeast S cerevisiae, not adapted for surviving in the digestive tract, C albicans was an immunogen for ASCA, that other CD serological markers named anti-laminaribioside carbohydrate antibody and anti-chitobioside carbohydrate antibody against glucans and antichitin (which are yeast cell wall polysaccharides as well as mannnan) were also generated by C albicans pathogenic development and, finally, that in families with CD, patients and also their first-degree relatives were colonised by C albicans in association with the presence of ASCA, suggesting a genetic defect in C albicans sensing." - http://www.ncbi.nlm.nih.gov/pubmed/23232049

So it could be worth experimenting with a yeast free diet. In one study on Crohn's disease patients with raised antibodies to bakers yeast, a yeast exclusion group had lower disease activity than the group that took supplementary yeast capsules indicating that intake of food allergens can adversely affect gut health - http://www.ncbi.nlm.nih.gov/pubmed/1502481

I am also allergic to casein (so is Sue) and I have found I do much better on a no dairy diet. In a trial of dairy elimination in SpA patients, 17/24 patients reported improvements, 8 were able to discontinue NSAIDs and in a two year follow up 6 no longer required any drug therapy - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1005380/

If you are going to investigate the potential candida connection, this site has some good info - http://www.nleducation.co.uk/resources/reviews/c-albicans-does-it-really-have-a-sweet-tooth/ . Also anti-fungal pharmaceuticals like nystatin may be effective.

Thank you jroc, that is very helpful. I'm torn between trying a yeast-free diet (based on the results of my food sensitivity test) and NSD. I've tried NSD before but believe I wasn't knowledgeable enough or prepared enough and ended up stopping before I could see results. It seems very challenging. In comparison a yeast-free diet seems far easier to maintain but I haven't seen anyone on these forums reporting results from going yeast-free the way they do for NSD.

so where do we find Saccharomyces cerevisiae in a NSD diet?

Probably wouldn't get much on an NSD diet as it eliminates bread which I'm guessing is likely to be the main dietary source. It is in marmite/vegemite and fermented products like beer/wine/vinegar. Some people also take nutritional yeast supplements.

HI everyone: ok quick question (newly diagnosed SA) gal here. I'm on day 2 of NSD . I also have a chronic yeast problem am taking Pure pro-biotics. (was on anit-biotics 2 years ago for MONTHS).

So far no change with yeast....I'm still eating fruit and honey

Question: 1. can i take Nystatin ORALLY one tsp daily to kill off yeast? If I'm off dairy and starches it doesn't leave me with much choice to get my carbs from carrots, squash and a little bit of fruit.

2) Is it true that some Pre-biotics feed the Kleb bacteria?


Supplments: Pure -probotic, magnesium bis-glycinat 600 mg, EPA high potency, GLA 400 mg, Cucurmin, Boswella, Vitamin D3 and K2, B-complex

I can help with question #1. I took Nystatin (4 tsp per day for 10 days) and Clotrimazole (10 MG lozenges 5 times a day for 10 days) for a few weeks and made daily diary entries about it at http://100percenthealth.us/year1-2/autoimmune-mold-enbrel-root-cause/.

For me, I didn't see that much benefit even though I tested higher for Yeast/Fungus. Turns out the water kefir I was taking was altering the test for my yeast.

The takeaway for you, though, is the amount I was prescribed. It looks to me like you are not taking enough and thus won't see any benefit from it.