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"The transition of acute to chronic bowel inflammation in spondyloarthritis"

Liesbet Van Praet, Peggy Jacques, Filip Van den Bosch & Dirk Elewaut

Abstract
That gut and joint inflammation are linked in spondyloarthritis (SpA) has been recognized for almost three decades. Intriguingly, microscopic gut inflammation, which occurs frequently in patients with SpA, is an important risk factor for clinically overt Crohn's disease and ankylosing spondylitis. This Review describes current insights into the underlying mechanisms that lead to chronic gut inflammation in patients with SpA. We propose that the development of chronic bowel inflammation in these individuals occurs through a transition phase, in which inflammation evolves from an acute into a chronic state. Our transition model implies that different cell types are involved at different stages during disease progression, with stromal cells having an important role in chronicity. In addition, deficient regulatory feedback mechanisms or genetically determined alterations in antigen presentation, endoplasmic reticulum stress, autophagy or cytokine signaling might also favor a transition from self-limiting acute inflammation to chronic inflammation. We anticipate that this transition phase might be an important window for therapeutic intervention.

The full article can be read at

http://www.nature.com/nrrheum/journal/v8/n5/full/nrrheum.2012.42.html

Regards David

as always,

thank you for the interesting journal articles that you link.

After the past 10+ years of unexplained pain, the past two being the worst....countless visits with doctors, multiple xrays, MRI's and bloodwork.....I finbally listened to my girlfriend and went to a Rheumy......she looked at all my tests, took 7 vials of bllod, LISTENED to me and when the blood work came in and I was positive for the HBL A27 gene.....I finally had a diagnosis and a plan of attack for this condition that has been at times too much to take.

But the best thing since my diagnosis was finding this web site and all the wonderful articles, ppl, definitions and INFORMATION...

I just want to thank you...as a newby here, for this article and all the rest I am sure I will find!