I was on Simponi for a year, the last month I started to flare and the AS was hitting places like my neck, shoulders, elbows, hands and knees. I was getting severe sciatica pain down my right leg and my hips started flaring again...Simponi did help for that year but it seems that like enbrel it lost its effectiveness. I'm on Humira now and it has helped most of the places I was flaring in other than my hips, which I'm hoping it will take care of that as well.
