Kickas.org Forums Ankylosing Spondylitis General Discussion #1 AS Web Support Group Intersting take from Patients of Dr Revelle in Hou

Dr Revelle is one of the lead researchers in AS. He was recruited by the SAA to try and specialize in AS research and focus on the genetics of the disease and improving treatment. Much of the member dues go to this cause.

A few of his patients, well two anyway, are saying he is not sure AS is an autoimmune disease but rater auto-inflammatory. In fact we may be auto deficient. This may tie into Ebringers Cell Death stuff partially but not a perfect fit for the cause of it if I am reading it right. Not enough info to really understand what he is saying and he says his research will be published "soon" I am not sure I understand the difference but I look forward to reading that.

And this is from Medscape

Summary: The study of autoinflammatory disease has progressed from genetics to definition of the functional defects in these patients. Although a direct association between defective innate immune responses to bacterial components and these diseases has not been formally established, much ongoing research is aimed towards confirmation of that hypothesis.

http://www.medscape.com/viewarticle/446203

another blurb
Mutations in genes encoding the tumour necrosis factor (TNF) receptor and pyrin superfamilies of molecules may lead to persistence of leukocytes that would ordinarily undergo apoptosis,

thanks for the info.

autoinflammatory was a new term for me so i googled it. interesting! will have to do more reading on the topic for sure.

saw that crohn's seemed to be listed under the topic. but then i am left wondering why enbrel would work for crohn's? maybe i need to do a bit more reading and my question will be answered.

also was thinking that if my inflammatory arthritis is autoinflammatory vs autoimmune then maybe LDN really is something to be considered more closely.

really thinking mostly about the disease classification and the treatment: biologics, LDN, etc.

interesting post, now to read up on autoinflammatory diseases.......

ok, did some more reading, think that answered a number of my questions,

seems like the articles i found still were saying it was a problem with the immune system, but more with the innate immune system vs the adaptive immune system which would explain the lack of antigen-antibody existence.

sounds like asking the question is it over active or under active is the new line of questioning, and what you were getting at.

overall interesting and would help explain seronegativity.

Just googled and it looks like they are calling coeliac (which I have) autoinflammatory as well rather than autoimmune. Interesting. Needs some more reading.

Yes. Was an article recently in Medical News Today on just that. Quite interesting. Have a chum who is coeliac - requires so much care to deal with (worse than IBD/crohn's!)

Yeah that was me who posted on SAA. Though I had almost wish I hadn't now. I think the old addage goes don't kill the messenger. They don't say anything about raking them over the coals though.

No taberge, on 'Medical News Today' - not SAA (I hardly ever visit SAA) prefer my KA and then doing my own digging...!! IF I have time will see IF I can find the original article...

You don't have to but it would be appreciated just for the extra reading.

I'm a celiac, diagnosed more than twenty years ago, and I have to say I think it's much easier to deal with than crohns. Follow the diet carefully and, bingo, you're good. No need for toxic drugs etc.

Now RA is a different kettle of fish altogether.

Hre's the google line-up -

Autoimmune Diseases Information

Aug 30, 2010 ... Autoimmune inner ear disease. Bullous pemphigoid. Celiac disease ... Autoinflammatory Disease Model Reveals Role for Innate Immunity - Researchers at ... Myasthenia Gravis can affect persons of any age as well. ... D in patients with autoimmune disease may be a result rather than a cause of disease ...

www.disabled-world.com/health/autoimmunediseases/ - Similar

PLoS Medicine: A Proposed Classification of the Immunological ...
Aug 29, 2006 ... Such a definition would encompass autoinflammatory mechanisms across the spectrum of ..... For example, the idea of coeliac disease being autoimmune in nature is ... including molecular imaging, as well as to determine the basis for ... and soft tissues, rather than a specific antigen territory. ...

www.plosmedicine.org/article/info%3Adoi%2F10.1371%2Fj... - Similar

Role For Innate, Not Adaptive, Immunity Revealed By ...
Jun 6, 2009 ... "Auto-inflammatory diseases are a relatively new classification of diseases that are different from autoimmune diseases or allergies," said ...

www.medicalnewstoday.com/articles/152679.php - Similar

Cooling Inflammation: Arthritis, Autoimmunity and Arginine ...
Feb 6, 2010 ... Arthritis of Joints Is Like Coeliac of Intestines; ... It is autoinflammatory as well as autoimmune. .... VitD is complex, because it is used as a hormone, rather than an enzyme cofactor like the other vitamins. ...

coolinginflammation.blogspot.com/2010/02/arthritis-au... - Similar

[PDF]Neutrophilic Cutaneous Lupus Erythematosus
of auto-immune and auto-inflammatory diseases as well ... manifestations will rather be the consequence of auto- ... Coeliac disease. Auto-immune bullous diseases of the skin ... Using a protein array for more than 100 cyto- ...

content.karger.com/produktedb/produkte.asp?typ=fulltext&fi... - Similar

Informa Healthcare - Autoimmunity - 0(0): - Full Text
Apr 7, 2010 ... celiac disease. AD. atopic dermatitis. AIT. autoimmune thyroiditis .... disequilibrium (LD) pattern in our data set, as well as for deriving the haplotypes. .... NLRP3 mutations lead to hereditary auto-inflammatory syndromes, ... effect of rs10754558 could be systemic rather than organ-specific. ...

informahealthcare.com/doi/pdf/10.3109/08916930903540432 - Similar

PEST family phosphatases in immunity, autoimmunity, and ...
... celiac disease, psoriasis, psoriatic arthritis, and multiple sclerosis. ... (53) observed a decrease, rather than an increase, in TCR-mediated responses, .... day 9.5) as well as severe abnormalities in embryonic vascularization, .... Similarly to autoimmune diseases, autoinflammatory disorders are ...

onlinelibrary.wiley.com/doi/10.1111/j.1600-065X.2008.00747... - Similar

Cell Damage and Autoimmunity: A Critical Appraisal
Also recognized are certain diseases, referred to as autoinflammatory at least .... signal necessary for the induction of autoimmune disease rather than tolerance. ... Celiac disease stands out as an autoimmune disorder where the ... a global need exists for better early signals of autoimmune disease than just ...

www.ncbi.nlm.nih.gov/pmc/articles/PMC2231525/ - Similar

Blood -- Autoimmunity in human primary immunodeficiency diseases
The prevalence of SIgAD in patients with celiac disease is 2.6%, which represents a 10- to .... as well as with scientists in laboratories around the world. .... 2B4 molecules displaying inhibitory rather than activating function are ..... TNFRSF1A mutations and autoinflammatory syndromes. Curr Opin Immunol. ...

bloodjournal.hematologylibrary.org/cgi/content/long/99/8/2... - Similar

Research articles: The New England Journal of Medicine
Identification of a Novel Antibody Associated with Autoimmune Pancreatitis ... malabsorption and deficiencies of calcium and vitamin D, rather than a… ... were identified in a man with celiac disease who presented with severe .... An Autoinflammatory Disease with Deficiency of the Interleukin-1–Receptor Antagonist ...

www.nejm.org/medical-articles/research?category=research&t... - Similar