Kickas.org Forums Ankylosing Spondylitis General Discussion #1 AS Web Support Group ARTS1 & IL23R genes identified AS association

i just read two more genes have been identified that are associated with ankylosing spondylitis. These genes are called ARTS1 and IL23R.

https://www.kickas.org/ubbthreads/ubbthre...true#Post270323

worth the visit !!!

ARTS1 has now been renamed ERAP1 since this article was published.

Researchers in Australia point to IL23 variants as being predictive as to how severe AS will be. ERAP1 is getting the most attention in research now.

The first IL 23 drug is now on the market for psoriasis and the first IL 17 drug is in trials for AS in Europe as I type.

The association of genes ARTS1/ERAP1 and IL23 were discovered and published in March 2007. On January 10, 2010, information about the discovery of two additional genes, ANTXR2 and IL1R2 as well as two gene deserts, was published. The TASC gene study also confirmed the previously reported gene associations (ERAP1 and IL23).
http://esciencenews.com/articles/2010/01....form.arthritis

Thanks Stormy for posting that e science update.

ANTXR2 gene codes for the protein ANTXR2 that stands for Anthrax Toxin Receptor 2.
ANTXR2 is also called CMP2 (capillary morphogenesis protein 2)
Deleterious mutations in the gene encoding CMP2 are the cause of Juvenile Hyaline Fibromatosis (JHF) and Infantile Systemic Hyalinosis (ISH), autosomal recessive diseases characterised by multiple subcutanoeus skin lesions, gingival hypertrophy and hyaline deposition.
Of interest CMP2 also functions as a cellular receptor for anthrax toxin
Anthrax is a sporing bacillus (Bacillus anthracis) famous as biologic weapon, re 9/11 period, when it was posted as white powder to a number of ?politicians.

Quote from the Nature Genetics Paper
"A functional explanation for this association (CMP2) with AS is not clear"