I drive for a living and it's absolutely unbearable at times, I am lucky in a way where I never drive for more than 20min roughly before I reach any stops I make. I have a big lumbar support which does help in the mid spine (lumbar and sacrum are already fused) NSAID'S help but not much... I pull over every 20 minutes or so and walk around parking lots or tim hortons (oh, Canada) compiled these all help but often not very much.
wish you the best!