Does anyone here know from experience if nsaids can cause depression? I have been on etodolac 400mg extended release for about 4 months now. For the last couple of months I have had some pretty strong depression. I've always had a tendency to get down at times, but usually not too far and for not too long. Most of the time I'm upbeat and happy. Lately though, there are many nights (like tonight for example) where I'm sort of thinking at the back of my mind that it sure would be nice to just go to sleep and not ever wake up. I often stop and try to think of reasons why I am happy to be alive and can't really think of any, or things I am actively looking forward to or excited about in the near or far future and can't think of even one thing.

I hate feeling like this and just really can't pin it on anything other than maybe cumulative stress or the meds or both. Have been talking to my doc about it. We tried a couple of anti-depressents and neither one lasted more than 3 days, couldn't stomach them at all. Am planning to see a pyschiatrist soon to get their input on it, but just wondered if anyone here had experienced a noticeable change in depression with any nsaids.

Last edited by txfast; 01/18/11 05:51 AM.

If you wanna live life on your own terms
gotta be willing to crash and burn