This is what I got Molly:
The researchers used individual questions to discriminate between people with and without AS. Question items with a significant positive relationship to AS included male sex as well as others. While it seems reasonable to expect that disease screening be gender-blind, in fact, gender plays an important role in determining a person's likelihood of having a particular disease.
We know that many women get this disease. However, we cannot ignore the fact that among people with similar symptoms, the male is more likely to demonstrate as having AS. Any research project that chose to ignore this fact would not be considered to be valid.Regarding the answer you got from SAA:
raise the economic burden (additional medical evaluations) from the payer perspective
To translate for those who are not intimately involved with the American health care system,
"payer" = "insurance company".