Hi Fonzy, she's right about having to exhaust other med avenues before starting on biologics. Sulfasalazine has been known to have very good results. Ask Mig about it, as she was on it for years.
You'll get used to giving yourself needles. My sweetie is on Enbrel and I've had to learn to give him needles, as you cannot inject the same site too frequently. The usual is both thighs, both sides of the abdomen, then both arms, then you go back to the first thigh you injected six weeks before. It's kind of hard to inject your own arm, so your wife will have to learn to do this, as well as you. It's easy, once you get started.
She's right about the stretching and PT to maintain the mobility you have. But she's not entirely right about AS burning itself out eventually. Some people go into remission for years, and alot of people experience a decrease in pain levels when fusing is complete in an area, but that's about it.
You and your wife can still enjoy a happy retirement together. I know I sound like a broken record on this, but you just may have to adjust how you do things, and how you look at life.
I know it's all very overwhelming for you right now, but I promise, eventually it will get easier.
Hugs,
