Wow! Thanks you guys. That was a really great explanation Strutsy, it helped me understand why I'm taking the folic acid. How long did it take for methotrexate to work for you? (Or anyone reading this post?) Or did you say you didn't really respond to it at all? Anyone who is reading, if you have comments about mtx I would love to hear them. I just don't know that much about it. I read a recent study (can't remember where) that said mtx hasn't shown that it really helps in AS patients. But I know I've read where it's really helped some of you, so maybe it was a biased study. I don't know. I'm giving it a shot. Anything is worth a try I guess. Thanks everyone!