I don't know to much about all of the medications. But I was on Vioxx which was more harmful than what I have switched to. I have heard and doctors have said as well that Mobic is not as harmful to the liver as the older ones. This anti-inflammatory is working great for me. It is very new and I have heard that it is better. I am 21 and really small and need to really watch out for my liver and kidneys with these meds. I hope that helps.