I had some tingling at level of knee, going down into my foot, along with pain. Pain doc was on it in a flash with MRI and nerve conduction testing. MRI showed sciatica, though the nerve conduction didn't show any deficits. She bumped up the pain meds for a time and showed me some stretches. And did an epidural a couple of times to quiet it down. Since that bad attack, it's kicked up a couple more times for a few days but never to the same level. For me this predated any biologics, so there wasn't a risk of MS, which is likely what the rheumy is ruling out. Good luck.