I have had severe headaches that I never experienced prior to being on Humira. When I told my Rheumatologist, she suggested taking 2 extra-strength Tylenol just before I inject my Humira. Since I started doing that, I haven't had a "Humira Headache". Now I just take one extra-strength Tylenol and it seems to do the trick. It's odd, since taking Tylenol, etc., *after* the Humira Headache hit never helped a bit. But it seems to help if taken as a preventative measure (prior to injection).