I have a friend who has extra high triglicerides from genes. His doctor had him try statins _twice_ and both times he ended up getting really sick from them (well-known statin syndrome with severe muscle aches and I forget what else). Then he figured out that statins were just not going to work out and ended up with "prescription strength fish oil". I guess that's been working ok without the horrid statin side effects.
a statin gave me terrible edema. also made me very nauseated. but it did wipe out the cholesterol.
now however, when i eat a very low carb diet (no starches, very little sugar), eat my nuts, take my fish oil, and walk, my triglycerides are excellent and HDLs are pretty decent too. think the only way i'll lose the LDLs is to lose the weight.