Hi James and thanks, how are you feeling today, any improvement? I certainly hope so, you've had a rough go of it...I'm not sure if Apermilast has a different potency than the other biologics but I'm sure when I get the trial packet it'll have that info in it, when I did the clinical trials for Enbrel, we were supplied with a library of info on it...I am wondering if there's a different absorption rate since it's going through the stomach, that may somehow make it more effective and I know it targets IL23 (the Interleukin 23 gene) that we've been hearing about so much lately.