I am in an AS flare and last week was given a big shot of steriod--I assume prednisone--and have been bouncing around with my mood...my poor husband must think I have flipped my lid because one minute I am fine and the next I am grumping at him! The swelling in my hands went down for several days but my sacrum is hurting BAD....The prednisone can help but has bad side effects. I really don't know what to tell you dear. It all depends on what YOU think is right for YOUR body. I wish you blessings and well being.