Kickas.org Forums Treatments, Drugs and Alternatives Anti TNF and other biological medications Precancer of Uterine Cervix following Biologics

Strewth - http://ard.bmj.com/content/early/2015/03/05/annrheumdis-2014-206909?papetoc

Malignant progression of precancerous lesions of the uterine cervix following biological DMARD therapy in patients with arthritis
René Cordtz1, Lene Mellemkjær2, Bente Glintborg1, Merete Lund Hetland3,4, Lene Dreyer1
+ Author Affiliations

1Department of Rheumatology, Copenhagen University Hospital Gentofte, Hellerup, Denmark
2Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark
3DANBIO Registry and Center for Rheumatology and Spine Diseases, Glostrup Hospital, Glostrup, Denmark
4Faculty of Health and Medical Sciences, Department of Clinical Medicine, University of Copenhagen, Denmark
Correspondence to
René Lindholm Cordtz, Department of Rheumatology, Copenhagen University Hospital Gentofte, Entrance 5, 3rd floor, Kildegårdsvej 28, Hellerup 2900, Denmark; rcordtz@gmail.com

Published Online First 5 March 2015

Patients with rheumatoid arthritis (RA) are more frequent chronic carriers of high-risk human papilloma virus (HPV) strains compared with the background population—an important risk factor for developing cervical cancer—and patients with RA have an increased risk of high-grade cervical dysplasia (CD) and cervical cancer.1–3 Little is known about the safety of biological disease-modifying antirheumatic drug (bDMARD) treatment in arthritis patients with a history of premalignant lesions.

We aimed to investigate how often female patients with inflammatory arthritis (RA, ankylosing spondylitis, psoriatic arthritis or other) and a history of premalignant lesions of the uterine cervix developed cervical cancer or another HPV-associated cancer according to ever versus never exposure to bDMARDs.

The nationwide Danish DANBIO Registry started in 2000 and covers >90% of adults with rheumatological disease treated with bDMARDs in routine care.4 Since 2005, patients not treated with bDMARDs have also been registered. We linked 15 238 female patients identified in DANBIO …



What the... <shakes head> Sigh.

Thanks Molly. Seems like we're at higher risk of just about everything. ... did you read the article itself to find out whether biologics increased or decreased the risk?

Biologics may increase the risk - but everyone is different. Will only effect a percentage, and may be a rare side effect. Yes, I did read the article. Oh well, onwards and upwards !

It's a risk. So is winding up fused and disabled. Ladies, get your pap smears. Young ladies (and gentlemen, I suppose), get your HPV vaccines (yes, you can get them on biologics).

HPV vaccine ? Suggest anyone looking at this vaccine checks out the side effects - yes, we are all different, but far too many young lives have been curtailed and threatened by the HPV. Great for pharma to develop and then for it to be pushed. Appalled. Fellas can be circumcised. Gals can ensure that fellas wear a condom. These are the best two ways to control the problem.

Nuns do not have a HPV problem - as was pointed out a meeting I attended some years ago - addressed by an eminent *male gynae. And found only rarely amongst the circumcised community.

With the correct precautions and 'correct' or 'circumscribed' behaviour, HPV vaccine can be left from where it should never have evolved, in the lab. *Firmly, in the 'back' of the lab.

As for 'fused and disabled' might not be disabled. As indeed I am not - fused cervicals and thoracics. Far more problems from osteophyts jamming into my aesophagus. One works around these problems - as possible.

What are the actual results of this study? The link leads to a paid article without citing any actual results? What are the risks? Why the scary icon without citing actual risks/results?

http://ard.bmj.com/content/early/2015/03/05/annrheumdis-2014-206909.short?g=w_ard_ahead_tab

All links lead to a payment per article. Maybe after some time that article might be available for free, but at the moment, no.

It is cited under the EULAR and ASAS banners and Denmark seem to be eagerly researching many aspects of RA and AS : Anals of Rheumatic Disease - https://twitter.com/ard_bmj

As for the icon - disagree as to 'scary', more 'heigh guys, might be an idea to check this out'!

So glad you brought that up, because I'm a pediatrician and vaccines (and vaccine denialism) is a topic near and dear to my heart, having so many people sick with preventable illnesses. So far NO lives have been curtailed or threatened by the vaccines and the side-effects of the HPV vaccine are mild and non-life threatening.

Last year in the USA, 20.4 MILLION doses were given. About ten thousand reported mild adverse effects after, such as fainting and dizziness (with rates of these two similar to placebo injection...because getting shots can cause fainting and dizziness, even if it's just saline), nausea, headache, fever (with no mention of whether the fever was associated with other symptoms like cough or congestion to suggest that it was caused by something else). 1 in 145,000 people suffered serious fainting. 1:248,000 suffered blood clots (which is roughly what would be expected in the study period for a healthy population). 1:1,000,000 suffered a serious neurological condition called transverse myelitis, which occurs in that age group at a rate of about 1:1,000,000. There has never once been a death that has been credibly associated with the HPV vaccine. 20 people died within a year of receiving the vaccine. Of the deaths that could be attributed (I think it was 12 of them) none was found to be likely related to the vaccine (mostly auto accidents and other trauma). There was no unusual clustering of deaths or severe adverse events after the vaccine to suggest that they were associated with the vaccine. The only side-effect of the vaccine that has been shown to happen much more than placebo is pain at the injection site.

If we assume, for the sake of argument, that all 20 deaths were directly caused by the vaccine, then the lifetime chance of dying of the vaccine is about 150,000:1. Your lifetime chance of dying of cervical cancer is 500:1. Your lifetime chance of dying of other HPV-associated cancer are more like 300:1. Your lifetime risk of dying in a car crash is 260:1.

Nuns can and do get HPV. In medical school, I participated in a partial colectomy for metastatic cervical cancer on a nun (I did my rotation in a Catholic hospital). Casual contact is sufficient to spread the virus. Before the introduction of the vaccine, 46% of female adolescents tested positive for HPV prior to sexual debut.

(Sources: CDC website and published materials, ACIP published materials, Personal communication with Dr. Anna-Barbara Moscicki)

Was there other information on side-effects you wanted me to check out for you?

Young people on immunosuppressants should get that vaccine and all other approved inactivated vaccines.

http://aolbroadband.search.aol.co.uk/aol...ry%20or%20death

JW Investigates HPV Injury Compensation Program - Judicial Watch
www.judicialwatch.org/.../hpv-vaccine-injuries-and-deaths-is-th... - Similar to JW Investigates HPV Injury Compensation Program - Judicial Watch
20 Mar 2013 ... Documents Obtained by Judicial Watch Reveal 200 Claims Filed with HHS for HPV Vaccine Injuries and Deaths, 49 Compensated. Documents ...

Gardasil Vaccine the Truth | The Truth About Gardasil | HPV ...
truthaboutgardasil.org/ - Similar to Gardasil Vaccine the Truth | The Truth About Gardasil | HPV ...
What they are not telling you is that thousands of girls are having adverse reactions to the HPV Vaccines, some have even died -at last count, over one hundred ...
The HPV vaccine: injuries and treatment - Natural Blaze
www.naturalblaze.com/.../the-hpv-vaccine-injuries-and-treatment.html
15 Oct 2014 ... India has cancelled the HPV vaccine trials after 7 deaths and multiple ... Most HPV vaccine injured have over 15 symptoms simultaneously.

6248 Permanent Injuries and 144 Deaths Following Gardasil HPV ...
healthimpactnews.com/.../6248-permanent-injuries-and-144-deaths... - Similar to 6248 Permanent Injuries and 144 Deaths Following Gardasil HPV ...
10 Dec 2013 ... 6248 Permanent Injuries and 144 Deaths Following Gardasil HPV ... Study: HPV Vaccine Linked to Premature Menopause in Young Girls.

HPV Vaccine Is Associated with Serious Health Risks - Mercola
articles.mercola.com/.../hpv-vaccine-effectiveness.aspx - Similar to HPV Vaccine Is Associated with Serious Health Risks - Mercola
16 Jul 2013 ... "Judicial Watch wants all records relating to the VICP, any documented injuries or deaths associated with HPV vaccines and all records of ...
Death and disability following HPV vaccination - ...
vaccine-injury.info/gardasil.cfm - Similar to Death and disability following HPV vaccination - ...
"Gardasil will become the greatest medical scandal of all times because at some point in time, the evidence will add up to prove that this vaccine, technical and ...

HPV Vaccine | A Shot of Truth
www.ashotoftruth.org/vaccines/hpv-vaccine
The Obama Administration did not investigate the HPV vaccine injuries and deaths but did spend $1.2 million of taxpayers' money to promote the Gardasil(tm ) to ...

http://articles.mercola.com/sites/articles/archive/2013/07/16/hpv-vaccine-effectiveness.aspx

(snip...) "Case Report of a Gardasil Death Confirms Presence of HPV DNA Fragments

Earlier this year, a lab scientist, who discovered HPV DNA fragments in the blood of a teenage girl who died after receiving the Gardasil vaccine, published a case report in the peer reviewed journal Advances in Bioscience and Biotechnology5. The otherwise healthy girl died in her sleep six months after receiving her third and final dose of the HPV vaccine. A full autopsy revealed no cause of death.

Sin Hang Lee with the Milford Molecular Laboratory in Connecticut confirmed the presence of HPV-16 L1 gene DNA in the girl's postmortem blood and spleen tissue. These DNA fragments are also found in the vaccine. The fragments were protected from degradation by binding firmly to the particulate aluminum adjuvant used in the vaccine.

"The significance of these HPV DNA fragments of a vaccine origin found in post-mortem materials is not clear and warrants further investigation," he wrote.

Lee suggests the presence of HPV DNA fragments of vaccine origin might offer a plausible explanation for the high immunogenicity of Gardasil, meaning that the vaccine has the ability to provoke an exaggerated immune response. He points out that the rate of anaphylaxis in girls receiving Gardasil is far higher than normal—reportedly five to 20 times higher than any other school-based vaccination program!

HPV Vaccine Is Associated with Serious Health Risks, Including Sudden Death

Many women are not aware that the HPV vaccine Gardasil might actually increase your risk of cervical cancer. Initially, that information came straight from Merck and was presented to the FDA prior to approval6. According to Merck's own research, if you have been exposed to HPV strains 16 or 18 prior to receipt of Gardasil vaccine, you could increase your risk of precancerous lesions, or worse, by 44.6 percent.

Other health problems associated with Gardasil vaccine include immune-based inflammatory neurodegenerative disorders, suggesting that something is causing the immune system to overreact in a detrimental way—sometimes fatally.

Between June 1, 2006 and December 31, 2008, there were 12,424 reported adverse events following Gardasil vaccination, including 32 deaths. The girls, who were on average 18 years old, died within two to 405 days after their last Gardasil injection
Between May 2009 and September 2010, 16 additional deaths after Gardasil vaccination were reported. For that timeframe, there were also 789 reports of "serious" Gardasil adverse reactions, including 213 cases of permanent disability and 25 diagnosed cases of Guillain-Barre Syndrome
Between September 1, 2010 and September 15, 2011, another 26 deaths were reported following HPV vaccination
As of May 13, 2013, VAERS had received 29,686 reports of adverse events following HPV vaccinations, including 136 reports of death,7, as well as 922 reports of disability, and 550 life-threatening adverse events
Lawsuit Reveals Payouts of Nearly $6 Million to HPV Vaccine-Damaged Victims

On February 28, 2013 the government watchdog group Judicial Watch announced it had filed a Freedom of Information Act (FOIA) lawsuit against the Department of Health and Human Services (DHHS) to obtain records from the Vaccine Injury Compensation Program (VICP) related to the HPV vaccine8. The lawsuit was filed in order to force the DHHS to comply with an earlier FOIA request, filed in November 2012, which had been ignored. As reported by WND.com9:

"Judicial Watch wants all records relating to the VICP, any documented injuries or deaths associated with HPV vaccines and all records of compensation paid to the claimants following injury or death allegedly associated with the HPV vaccines... The number of successful claims made under the VICP to victims of HPV will provide further information about any dangers of the vaccine, including the number of well-substantiated cases of adverse reactions."

On March 20, Judicial Watch announced it had received the FOIA documents from the DDHS, which revealed that the National Vaccine Injury Compensation Program has awarded $5,877,710 to 49 victims for harm resulting from the HPV vaccine. According to the press release10: "On March 12, 2013, The Health Resources and Services Administration (HRSA), an agency of HHS, provided Judicial Watch with documents revealing the following information:

Only 49 of the 200 claims filed have been compensated for injury or death caused from the (HPV) vaccine. Of the 49 compensated claims, 47 were for injury caused from the (HPV) vaccine. The additional 2 claims were for death caused due to the vaccine.
92 (nearly half) of the total 200 claims filed are still pending. Of those pending claims, 87 of the claims against the (HPV) vaccine were filed for injury. The remaining 5 claims were filed for death.
59 claims have been dismissed outright by VICP. The alleged victims were not compensated for their claims against the HPV vaccine. Of the claims dismissed, 57 were for injuries, 2 were for deaths allegedly caused by the HPV vaccine.
The amount awarded to the 49 claims compensated totaled 5,877,710.87 dollars. This amounts to approximately $120,000 per claim.
This new information from the government shows that the serious safety concerns about the use of Gardasil have been well-founded," said Judicial Watch President Tom Fitton. "Public health officials should stop pushing Gardasil on children."
(more...)

[-] Sources and References
1 Source Removed
2 The ONC July 1, 2013
3 Journal of Infectious Diseases 2013 Aug;208(3):385-93
4 The ONC July 1, 2013
5 Advances in Bioscience and Biotechnology 2012(3); 1214-1224
6 FDA.gov Gardasil™ HPV Quadrivalent Vaccine May 18, 2006 VRBPAC Meeting (PDF)
7 MedAlerts.org. HPV vaccine adverse event report to VAERS as of May 13, 2013. Accessed July 10. 9, 2013.
8 Judicial Watch February 28, 2013
9 WND.com March 11, 2013
10 Marketwatch.com March 20, 2013, Judicial Watch Press release
11 Current Pharmaceutical Design 2012 Sep 24. [Epub ahead of print]
12 New England Journal of Medicine 2006; 354:2645-2654
13 Assembly Bill