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Joined: Feb 2006
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drizzit Offline OP
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WOW. That is a bit eye opening to me. Completely inhibiting IL 23 could have huge impact on AS and it is a pill

voclosporin is the drug name and check this out

"Voclosporin Suppression of Human T Cell Cytokine Secretion
Compared with cytokine secretion from vehicle-treated cells, CD3/CD28-stimulated human T cells, incubated with various levels of voclosporin, had decreased Th1, Th2, and Th17 cytokine release proportional to the voclosporin dosage. Specifically, Th1 cytokine levels for IFN- (vehicle, 2084 701 pg/mL; 100 nM voclosporin, 22 13 pg/mL) and TNF- (vehicle, 787 127 pg/mL; 100 nM voclosporin, 20 8 pg/mL) were reduced up to 300-fold and 58-fold, respectively (Fig. 6A) . Th2 cytokine levels for IL-4 (vehicle, 49 6 pg/mL; 100 nM voclosporin, 0.9 0.3 pg/mL), IL-5 (vehicle, 154 23 pg/mL; 100 nM voclosporin, 18.9 0.7 pg/mL), IL-10 (vehicle, 1048 83 pg/mL; 100 nM voclosporin, 8.6 5.6 pg/mL), and IL-13 (vehicle, 312 24 pg/mL; 100 nM voclosporin, 50.8 23 pg/mL) were reduced up to 37-fold, 7-fold, 322-fold, and 10-fold, respectively (Fig. 6B) . Th17 (IL-17) levels (vehicle, 1077 158 pg/mL; 100 nM voclosporin, 72.6 12.2 pg/mL) were reduced up to 20.5-fold, whereas IL-23 levels were completely inhibited (vehicle, 14 14 pg/mL; 100 nM voclosporin, 0 0 pg/mL; Fig. 6C )."



Source:
http://www.iovs.org/cgi/content/full/50/1/249


No families take so little medicine as those of doctors, except those of apothecaries.

Oliver Wendell Holmes
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Wow. Sounds like a pretty potent immune suppressant.

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drizzit Offline OP
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it has also completed a phase 3 trial for psoriasis

http://www.isotechnika.com/in_development/voclosporin/psoriasis/

Yea this one looks to be a BIG GUN lol especially for a pill


No families take so little medicine as those of doctors, except those of apothecaries.

Oliver Wendell Holmes
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any idea of the cost? thats good that the psoriasis trial didn't show any clinically significant changes in infectious complications.

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drizzit Offline OP
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no clue on costs but as a chemical drug I suspect it will be significantly cheaper than the TNF and other biological drugs.

FDA may hold it up as well. It appears a meeting was cancelled but the review date held so there must be some questions. That is not unusual for a drug on the fast tract like this one is. Europe is also reviewing the drug with a decision due in the spring of next year.

Last edited by drizzit; 07/01/10 01:51 AM.

No families take so little medicine as those of doctors, except those of apothecaries.

Oliver Wendell Holmes
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That is really interesting, and it looks v promising. Thanks for posting.


"Traveler, there is no road, you make your path as you walk." - Antonio Machado
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Dow Offline
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I tried to read all that- I think it made my iritis worse, ha ha eek2

I need somebody to explain it to me more like this:

"Well, CD3/CD28 is like Princess Leia, when she was captured by Jabba The Hut. (played by TH17(IL17). She needs help. Meanwhile, Cytokine is like Darth Vadar plotting from the Death Star. But don't worry, Voclosporin is Luke Skywalker, flying in a landspeeder to the rescue!"

THAT kind of thing I can understand! yes


Dow

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