How were you taking your LDN, was it compounded in tablet (pill) form?
A common filler compounding pharmacies use in tablet form is "Avicel", and there are reports of people doing poorly, not just with Avicel, but with various fillers (lactose, etc.) depending on the individual.
My compounder could not find a cost effective solution to let me have acidophilous as a filler, so I went with the pure Naltrexone powders in distilled water (liquid LDN, refrigerated). This way it's been easy to play around with dosage. Have settled on 3mg for now, as I'm thinking 4.5mg makes me grumpier - not sure how true that is... I'm guessing I'd do better without work in general, er, I mean, work stress!http://www.lowdosenaltrexone.org/gazorpa/LDNFillers.html