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Joined: Aug 2003
Posts: 2,717
ironchef
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ironchef
Joined: Aug 2003
Posts: 2,717
(note: in the testing of enbrel for efficacy in several different disease the immunex folks
also used some tripple variable testing...they tested enbrel against a placebo; enbrel against methotrexate; and enbrel with methotrexate (for RA test)...)

the follwing are their test results for methotrexate, reporting adverse events/complaints

percent of patients,,,methotrexate by injection
injection site reaction 7
infection(total) 72
-non uri infections 60
-uri infections 39
headache 27
nausea 29
rhinitis 14
dizziness 11
pharyngitis 9
cough 6
abdominal pain 12
rash 10
peripheral edema 23
respiratory disorder 4
dyspepsia 10
sinusitis 3
vomiting 8
mouth ulcer 14
alopecia 12
pneumonitis(mtx lung) 2
copywrite 1998-2007 immunex
pub 02-01-07


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Posts: 2,717
ironchef
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ironchef
Joined: Aug 2003
Posts: 2,717
i added not a word of commentary.

i don't even know some of the terms.

friends don't let friends take methotrexate


Joined: Jul 2003
Posts: 2,958
Presidential_AS_Kicker
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Presidential_AS_Kicker
Joined: Jul 2003
Posts: 2,958
hi Ben.
Thanks for the post. Those are some high percentages!! Infections 72%, whoa. Abdominal pain is much less than I thought it would be.
take care,
James.


HLA-B27+, JRA diagnosis in 1981, re-diagnosed as AS in 1988. Also iritis, colitis, and psoriasis. NSD + low carb helps me.
Joined: Sep 2001
Posts: 1,661
Platinum_AS_Kicker
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Platinum_AS_Kicker
Joined: Sep 2001
Posts: 1,661
Ben, I took MTX for 7 yrs. I got infections from even paper cuts. I had to bandage every tiny cut and use neosporin until they healed. If I forgot, even a paper cut would wake me up throbbing that night. Funny, despite risk of infection, I haven't had a single one since switching to enbrel (fingers crossed) around 4 yrs ago.



This bunny Kicks AS !
Joined: Jun 2006
Posts: 1,873
Lieutenant_AS_Kicker
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Lieutenant_AS_Kicker
Joined: Jun 2006
Posts: 1,873
I love you Ben.

AMEN.

-Bridge




"Laughter is the shortest distance between two people." -Victor Borge
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Hi Ben,

I thought methotrexate was hard on the liver as well. I recall my doctors stating it was not an option for me after i had liver issues with azulfadine.

Tim


AS may win some battles, but I will win the war.

KONK - Keep ON Kicking
Joined: Sep 2001
Posts: 8,397
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Very_Addicted_to_AS_Kickin
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Very_Addicted_to_AS_Kickin
L
Joined: Sep 2001
Posts: 8,397
Ben,
like others, I love you as a good brother.
It nearly killed me with the swollen brain.


I keep the New Covenant,
when I fail....I am pulled
back into place by HIM.
Joined: Aug 2008
Posts: 41
T
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T
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Posts: 41
Hi I am new to the board My daughter is 14 and on MTX
she had some of these same side effects with the pills but switched to the injections . It has eliminated her side effects almost completely , of course obviously she needs to be careful not to expose herself to sick people . Her side effects were not as serious as some of those listed but when she was feeling really awful after a pill dose and was throwing up and exhausted I asked her if it was worth it and she replied that the joint pain was so much worse that it was.
so I keep my fingers crossed and pray that the injections will continue to work ,that her side effects will stay away and that she will go into remission and that there will be no long lasting problems from the MTX. But when you have a kid that really could not even walk and then a few months later is playing sports again you really do jump on the cure ....other inflammatory medicines helped but none like the MTX so now she takes both it really has worked wonders for her... but scares me terribly

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ironchef
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ironchef
Joined: Aug 2003
Posts: 2,717
james, aloha

i was also astounded by these results...i discovered this table after being on mtx
for 10 months...just thought i'd share


Joined: Aug 2003
Posts: 2,717
ironchef
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ironchef
Joined: Aug 2003
Posts: 2,717
aloha bridge

love ya too...hope you're doing well.
pu liki


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