My mom has had issues for years. She was diagnosed last year with AS. Now my sister ( she loves me very much) has been told she has the famous HLA marker. She has been having increasing problems. She is taking the news head on. I did not sugar coat it, I figure she also has the Blackwell gene so she can take it She has been on here checking the site out. She said she joined the other day,not approved yet. So don't go easy on her she can take it.