I have heard that tinctures give you a "slow down" type of feeling that last around 5 hours, and provide pain relief. I've also heard that smoking gives you a quicker up feeling and pain relief a for a few hours and sometimes lasts longer, but has the lung effects, and increased appetite. I would not drive with either. Eat citrus fruit with.

Sometimes I think my body is an inflammation nation.

AS for 20 years
HLAb27+, i think there was talk a negative result at later date, but never confirmed.
Have been on many different anti- inflammatory drugs (naproxen to arthrotec to vimovo). Now off all prescription meds except occasional advil or tylenol.
Don't underestimate the power of icing (I bought the biggest ice pack i could find and it is good at numbing pain).