I started the NSD 12/20/10, and saw improvement from the pain within 3-4 days. I was diagnosed with pre-AS in 6/2010. By December it was affecting almost my entire body. Today, I almost feel normal again. I still take the sulfasalazine, and a couple of Ibuprofin twice a day, but there is no doubt in my mind the NSD strictly done is very beneficial. I discovered it on this sight, thanks to my daughter and wife. It has helped me regain my life again.