Science Daily
[color:#000099]"Large-scale analysis finds majority of clinical trials don't provide meaningful evidence[/colour] (May 1, 2012) -- The largest comprehensive analysis of ClinicalTrials.gov finds that clinical trials are falling short of producing high-quality evidence needed to guide medical decision-making. The analysis found the majority of clinical trials is small, and there are significant differences among methodical approaches, including randomizing, blinding and the use of data monitoring committees". ... > full story
http://www.sciencedaily.com/releases/2012/05/120501162702.htm

Journal Reference:
R. M. Califf, D. A. Zarin, J. M. Kramer, R. E. Sherman, L. H. Aberle, A. Tasneem. Characteristics of Clinical Trials Registered in ClinicalTrials.gov, 2007-2010. JAMA: The Journal of the American Medical Association, 2012; 307 (17): 1838 DOI: 10.1001/jama.2012.3424