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#519154 - 11/06/18 10:17 AM Advances in Spondyloarthritis: Glimpse the Future
MollyC1i Offline

Registered: 01/21/04
Posts: 9806
Loc: Brittany, France (since Nov 08...

Advances in Spondyloarthritis: Glimpse in the Future
Atul A. Deodhar

DISCLOSURES Curr Opin Rheumatol. 2018;30(4):301-302.

Research in the field of spondyloarthritis (SpA) races along all fronts – from investigating the complex role of gut microbiome in the pathogenesis, to new modalities of imaging and finding novel therapies. For a busy rheumatologist, it truly is difficult to stay up-to-date, considering the breathtaking speed of new discoveries in SpA. In this issue of the Current Opinion in Rheumatology, the reader will get a good glimpse of where we stand today, and where the field of spondyloarthritis is headed. (more...)


We've come a long way since I joined KA all those years ago. From 'only men and HLA-B27 positive and IF X-rays don't show, then, not AS !' To now. Multiples of genes may be involved, women, older age groups, MRI gold standard, SIs take time to reach screening levels. Diet no good, to diet being advocated. The Microbiome'. Yea. All good stuff and Profs Ebringer and Brown exonerated - though will 'they' ever admit that ? But *we know, innit <Big Grin>
Molly C - Keeping on, Keeping on - as we all do
MollyC1i - Riding OutAS

#519156 - 11/06/18 11:03 AM Nonradiographic Axial Spondyloarthritis [Re: MollyC1i]
MollyC1i Offline

Registered: 01/21/04
Posts: 9806
Loc: Brittany, France (since Nov 08...

How is nonradiographic axial spondyloarthritis distinguished from radiographic disease -- and how do management strategies differ?

Nonradiographic Axial Spondyloarthritis
Clinical and Therapeutic Relevance
Nilasha Ghosh; Eric M. Ruderman

DISCLOSURES Arthritis Res Ther. 2017;19(286)

Abstract and Introduction
Current classification criteria for axial spondyloarthritis (axSpA) provide for the inclusion of patients with a wide range of presentations and manifestations. While not considered a formal subclassification, patients are often divided into radiographic or nonradiographic axSpA based on the presence or absence of radiographic sacroiliitis. This review will focus on nonradiographic axSpA and will discuss clinical manifestations of disease that distinguish, or in many cases do not distinguish, this entity from other individuals with axSpA. This review will also cover treatment paradigms for nonradiographic axSpA, particularly the use of biologic therapies, where current data suggest that nonradiographic disease should be managed largely the same as radiographic disease, or classical ankylosing spondylitis."

(snip...) Search Strategy
"Information for the review has been drawn from manuscripts in the PubMed database published within the last 10 years. Search terms included "axial spondyloarthritis," "non-radiographic axial spondyloarthritis," "criteria AND axial spondyloarthritis," "inflammatory spinal disease," "[TNF inhibitors OR treatment] of axial spondyloarthritis," "biomarkers AND axial spondyloarthritis," "[predictors OR progression] of axial spondyloarthritis," "fibromyalgia AND axial spondyloarthritis," "therapy + axial spondyloarthritis" and "monitoring tools AND disease activity."


We've come a long way... !!
Keeping on, Keeping on - Yea
MollyC1i - Riding OutAS


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