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#517930 - 12/18/17 09:00 PM Re: COSENTYX? [Re: arsimoun]
doug7 Offline
Member

Registered: 05/28/09
Posts: 42
I loved Cosentyx-almost forgot I had PSA/AS. Humira, Cimzia, Cosentyx were the best biologics for me (had days where I felt normal again), but I build up resistance (probably anti-bodies) to all biologics after about 12 months.

There isn't overwhelming evidence to support being on MTX will stop antibody formation...it may just be how some of us are wired. Some can be on one biologic for years with great results. For me, it just stops working. Upping the dose can help, but it usually only gets me a few more months.

I took and liked Remicade, stopped because of the infusion services cost. I went back on it and had a terrible reaction-whole body reaction that put me in the hospital for a week. So if you build up antibodies to these things, once you are done with them, don't go back.

Check the pipeline of PSA/Psoriasis and other suppressants to pace yourself-for me they are not making them fast enough for me to go through them. :-/

Take care...

-doug

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#518594 - 04/22/18 12:35 AM Re: COSENTYX? [Re: arsimoun]
rumble Offline
Supreme_AS_Kicker

Registered: 01/31/09
Posts: 4485
Loc: NE Oklahoma
Update to my post above....after speaking with rheumy about the constipation side-effect, he wanted me to take a 3 month break from the Cosentyx and then reevaluate. He was a little incredulous that a med could cause first diarrhea, then constipation, despite me saying it didn't just switch from one to the other...it was gradual. So I just went back to see him after the break and said it was definitely the Cosentyx causing my problems. Gut issues had resolved over time. By the time I missed the 2nd dose, I was pretty sure things were getting better. By the time I missed the 3rd dose, it was certain.

I plan on going back to Cimzia after insurance approves it...they will since I've not had any issues getting approvals for the other 5 biologics. Hopefully it will work as well as it did before I had to stop it for pneumonia.

Hope those who are taking Cosentyx now are doing well with it.
_________________________
DX: Psoriatic Arthritis, Osteoporosis, Psoriasis
Meds: MTX since Oct 2009, 15mg/week. Cosentyx (6th biologic) starting soon.
Epidural Steroid Injections x7; Lumbar Radiofreq Ablation x2
SIJ Steroid Injection x3; Bilateral Radiofreq Ablation SIJ x8

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