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#517564 - 08/29/17 12:06 AM MRI resolve - AS
jay_bharat Offline
Decorated_AS_Kicker

Registered: 12/08/08
Posts: 708
Loc: INDIA, Tamil Nadu
Hi all,

If someone takes anti TNF (Bioligical injection) for AS, whether after a couple of years, any AS related issues will be resolved / reduced / disappear in the MRI image taken after anti TNF therapy compared to MRI image prior to anti TNF.

Regards.

Jay


Edited by jay_bharat (08/29/17 12:07 AM)

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#517565 - 08/29/17 05:10 AM Re: MRI resolve - AS [Re: jay_bharat]
Frederick Online   content
Second_Degree_AS_Kicker

Registered: 03/28/06
Posts: 202
Are you stating the above to be a fact or are you asking us if it is true?

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#517566 - 08/29/17 05:23 AM Re: MRI resolve - AS [Re: Frederick]
jay_bharat Offline
Decorated_AS_Kicker

Registered: 12/08/08
Posts: 708
Loc: INDIA, Tamil Nadu
It is a querry to know about the fact. I searched and understood that anti TNF resolves inflammation. But whether anti TNF halt the disease progression?. If MRI is taken after anti TNF treatment, whether disease progression will be there?. If it so, what are the images expected in MRI?.

Jay

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#517567 - 08/29/17 01:34 PM Re: MRI resolve - AS [Re: jay_bharat]
JayTeee Offline
New_Member

Registered: 04/05/17
Posts: 4
Hello Jay,

Response to Anti-TNF meds really depends on the person taking them - some people are excellent responders, whereas others do not respond as well. Anti-TNFs are able to resolve active inflammation, therefore if you are a good responder and receive MRI imaging some time afterwards, signs of active inflammation could disappear. However, signs of past inflammation might still be present, such as fat metaplasia, degenerative joint changes etc. If you start Anti-TNFs early enough, where no degenerative changes have occurred yet, MRI could theoretically be clear. All this info is based on my education and personal research. Hope that helps!

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#517572 - 08/30/17 05:52 AM Re: MRI resolve - AS [Re: jay_bharat]
Frederick Online   content
Second_Degree_AS_Kicker

Registered: 03/28/06
Posts: 202
Thanks for that JayTeee. Good to have some science on here for a change.

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#517574 - 08/31/17 09:05 AM Re: MRI resolve - AS [Re: JayTeee]
jay_bharat Offline
Decorated_AS_Kicker

Registered: 12/08/08
Posts: 708
Loc: INDIA, Tamil Nadu
Hi JayTree,

Thank you.

Quote:
However, signs of past inflammation might still be present, such as fat metaplasia, degenerative joint changes etc


Whether fat metaplasia, degenerative joint changes are due to inflammation. I thought atleast degenerative joint changes is age related issue.

Jay

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#517575 - 08/31/17 06:35 PM Re: MRI resolve - AS [Re: jay_bharat]
JayTeee Offline
New_Member

Registered: 04/05/17
Posts: 4
Degenerative joint changes can happen as a result of age, and that is usually the case. However, persistent inflammation in a joint can erode the joint cartilage and cause degeneration as well. Persistent inflammation also causes the body to deposit more bone to places where it is not supposed to, which leads to fusion of the inflamed joints. These are the things that you usually see on MRI.

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#517576 - 09/02/17 04:11 AM Re: MRI resolve - AS [Re: JayTeee]
jay_bharat Offline
Decorated_AS_Kicker

Registered: 12/08/08
Posts: 708
Loc: INDIA, Tamil Nadu
Thank you.

Jay

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