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#516942 - 04/20/17 09:27 AM Re: Tried Humira and Remicade and no what [Re: psr]
arsimoun Offline

Registered: 02/17/05
Posts: 23
FWIW, Humor stopped working for me; I formed antibodies to it. Sigh. Rheumie is trying to get me approved for Consentyx, Anyone have any experience with this drug?

Adam Rodman

#517442 - 07/20/17 06:48 PM Re: Tried Humira and Remicade and no what [Re: psr]
MikeGinnyMD Offline

Registered: 01/24/09
Posts: 68
Loc: SF Bay Area, CA, USA
Yeah, the problem with monoclonal antibodies, even the fully-human ones like adalimumab, golimumab, and secukinumab is that there is one little part of the antibody that is foreign to the patient, and that's the part that binds the TNF. About 1/3 patients will eventually form neutralizing antibodies.

The only one that has much less potential for this is etanercept. In the case of etanercept the entire protein is fully human and is found in every human living today. Antibody formation is much lower with etanercept.

#517446 - 07/21/17 03:02 PM Re: Tried Humira and Remicade and no what [Re: arsimoun]
snipe_Chief Offline

Registered: 07/16/09
Posts: 17
Loc: Virginia, USA
I'm on my 6th week of Cosentyx, 2 weeks since my last shot and I feel better than I have in years! You start with a series of 5 total weekly shots then go to monthly maintenance. So I'm two weeks away from my first monthly shot but it's holding strong. I was close to pain free in the first week. Yes, there's still pain and I can't walk for too long before I start to hurt, but I'm doing better that I have in years. I was unable to stay in bed longer than 6 hours due to pain prior to starting it, now I can get a good night's rest!

#517447 - 07/21/17 03:28 PM Re: Tried Humira and Remicade and no what [Re: snipe_Chief]
MikeGinnyMD Offline

Registered: 01/24/09
Posts: 68
Loc: SF Bay Area, CA, USA
Thanks for the story, snipe-Chief. I'm so glad to hear it's helping you. These drugs truly are miracles.

#517450 - 07/21/17 11:54 PM Re: Tried Humira and Remicade and no what [Re: psr]
rumble Offline

Registered: 01/31/09
Posts: 4475
Loc: NE Oklahoma
Good to hear the good you have with Cosentyx, snipe_chief. Will be starting it soon and hope for good results. Where in VA are you located? I'm visiting Tidewater area in 3 weeks (was stationed there back in early 80s at Ft Monroe) for an Army reunion. Great place to visit, but I wouldn't want to live there any longer. Enjoyed my time there, but I'm done with East coast--any of it. LOL.
DX: Psoriatic Arthritis, Osteoporosis, Psoriasis
Meds: MTX since Oct 2009, 15mg/week. Cosentyx (6th biologic) starting soon.
Epidural Steroid Injections x7; Lumbar Radiofreq Ablation x2
SIJ Steroid Injection x3; Bilateral Radiofreq Ablation SIJ x8

#517451 - 07/22/17 11:19 PM Re: Tried Humira and Remicade and no what [Re: snipe_Chief]
jay_bharat Offline

Registered: 12/08/08
Posts: 637
Loc: INDIA, Tamil Nadu

Whether the loading dose of 0,1,2,3,4 for cosentyx is required for who were on remicade, humira etc., Whether methotrexate to be taken while on cosentyx.


#517457 - Today at 05:22 PM Re: Tried Humira and Remicade and no what [Re: jay_bharat]
arsimoun Offline

Registered: 02/17/05
Posts: 23
I have been on Cosentyx since May. It seems to be working well for me. I was able to have cataract surgery (no Iritis since starting Cosentyx) after having to postpone three times when the Humira stopped working. Once you've done the initial loading period, you take only one injection a month. Very convenient.


Adam Rodman

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