Hello, Tigerlady:
Is this normal? Please give me some information on this problem. Thanks
I don't have direct experience with any biologic, but like them very much for their potential to reduce symptoms. Two months should not be long enough to develop antibodies to the Humira.
The
agent provocateur in AS is the immunoglobulin IgA-Kp, produced in response to the presence of the bowel germ
Klebsiella pneumoniae. This IgA reacts with most of our collagen tissues, especially type IV--that of which the uvea, lens capsule and other eye components are composed.
Regret our nemesis germ thrives upon our favorite foods, and I don't want to drive Your opinion about what You ate prior to the iritis flare; it is something to consider. There are a limited number of cytokines the biologic can neutralize, but the numbers of IgA we can produce are prodigious and can easily overwhelm. And just one IgA can eventually result in the production of many target (and non-targeted) cytokines.
I hope the "eye pain" You have experienced is not iritis, but in every similar situation I highly recommend a dietary approach in conjunction with every other therapy.
HEALTH,
John