banners
Kickas Main Page | Rights and Responsibilities | Donate to Kickas
Kickas Links
·HOME
·Forums Main Index
·Register!
MEDICAL CENTRE
·Medicine Contract
·AS Patient Guidebook
·Pain Map
·Disease Modification
·Ask your doctor
·AS and RA Papers
·AS Acronyms
DIET CENTRE
·London AS Diet
·Molecular Mimicry
·AS Dietary Primer
·AS Food Guide
SUPPORT CENTRE
·In Memorium
·KickAS Stories
·KickAS Banners
·Donations
Forum Stats
12,551 Registered Members
28 Forums
43,290 Topics
515,326 Posts

Most users ever online: 1,568 @ 06/29/16 03:25 PM
Newest Members
Chirag, Lynne1946, Maneesh, disshavler, AshleyH
12551 Registered Users
KickAs Team
Administrator/owner:
John (Dragonslayer)
Administrator:
Melinda (mig)
WebAdmin:
Timo (Timo)
Administrator:
Brad (wolverinefan)

Moderators:
- Tim (Dotyisle)
- Chelsea (Kiwi)
- Megan (Megan)
- Wendy (WendyR)
- John (Cheerful)
- Chris (fyrfytr187)

QR Code
If you want to use this QR code (Quick Response code) just save the image and paste it where you want. You can even print it and use it that way. Coffee cups, T-Shirts etc would all be good for the QR code.
Page 1 of 2 1 2 >
Topic Options
#511342 - 06/13/15 10:23 AM Low Birthweight/Childhood Infections / Predict AS
MollyC1i Offline
Very_Addicted_to_AS_Kickin

Registered: 01/21/04
Posts: 9701
Loc: Brittany, France (since Nov 08...
POLL...........

http://www.sciencedaily.com/releases/2015/06/150611082126.htm?

Low birth weight and childhood infections predict ankylosing spondylitis
Date:
June 11, 2015
Source:
European League Against Rheumatism
Summary:
The results of a new study showed that a diagnosis of ankylosing spondylitis can be predicted by low birth weight, having older siblings and hospitalization for infection between the ages of 5-16 years. These data suggest that these factors play an important role in the pathogenesis of the disease.
Share:
1 3 0 0
FULL STORY
The results of a study presented today at the European League Against Rheumatism Annual Congress (EULAR 2015) Press Conference showed that a diagnosis of ankylosing spondylitis (AS) can be predicted by low birth weight, having older siblings and hospitalisation for infection between the ages of 5-16 years. These data suggest that these factors play an important role in the pathogenesis of the disease.

AS is a painful and progressive form of arthritis caused by chronic inflammation of the joints in the spine. Prevalence of AS varies globally, and is estimated at 23.8 per 10,000 in Europe and 31.9 per 10,000 in North America.

The cause of AS is unknown. Although AS is strongly associated with the genotype HLA-B27, not everyone testing positive for the marker goes on to develop the disease.

"A link between AS and the HLA-B27 genotype was established more than three decades ago, yet studies on the environmental risk factors are few," said study investigator Dr. Ulf Lindström, Institute of Medicine, Rheumatology and Inflammation Research, Sahlgrenska Academy, Sweden. "Our research has identified three factors associated with significantly increased risk of the disease in later life. These data strengthen our understanding of the interplay between genetics and environment in AS, and bring us closer to pinpointing the underlying cause of the disease."

Statistically significant increased risks were observed for birth weight under 3,000g (18% vs. 15%), having older siblings (63% vs. 58%) and for hospitalisation due to infections at age 5-12 (5% vs. 3%) and age 13-16 (2% vs. 1%). These factors have been implicated in other, associated disease; the triggering effect of infections in reactive arthritis has been established, birth weight has been shown to predict development of autoimmune disease (diabetes and rheumatoid arthritis), and a link between older siblings and disease risk has been demonstrated in asthma.

Data from several Swedish national registers were used for this study, with five matched controls (sex, age, county) identified for each case of AS. Exposures assessed were birth weight, gestational age, type of birth (single/multiple), number of older siblings and exposure to infections.

Story Source:

The above story is based on materials provided by European League Against Rheumatism. Note: Materials may be edited for content and length.

cat

OK. Let`s see what we can come up with...

To start the ball rolling. Me.
Normal birthweight 7lbs 7ozs. Full term
Third child - so two older (and later two younger)
Childhood Infection - yes. At 7 yrs infection of some sort, fever etc, not Dx. Aged 10 yrs Scarlatina Nephritis, very ill. Discharged from further surveillance at aged 19yrs.

Next AS`er - see if we can agree this finding...

[/b][b]
_________________________
MollyC1i - Riding OutAS

Top
#511348 - 06/13/15 04:47 PM Re: Low Birthweight/Childhood Infections / Predict AS [Re: MollyC1i]
cemc Offline
Major_AS_Kicker

Registered: 01/25/10
Posts: 2105
Loc: UK
Interesting.

Me: Birthweight ? but three weeks early, and have an idea I was a bit small, and less than 7lb
Oldest (of three)
hospitalised for pneumonia and collapsed lung at age of 7 or 8, also nursed at home (by mum) through some fairly serious chest infections between aged 5 and 12

Top
#511350 - 06/13/15 06:14 PM Re: Low Birthweight/Childhood Infections / Predict AS [Re: MollyC1i]
gbash Offline
Master_AS_Kicker

Registered: 10/09/08
Posts: 890
Loc: Oklahoma
Hmmm...

- My birth weight was 8 lb 15 oz, so not underweight.
- Two older siblings.
- No childhood infections.
_________________________
AS symptoms started 1991. Official dx in 2006 with HLA-B27+, fused SIJ, bone spurs in back, extreme rib/hip pain, and other family with SpA. Started Enbrel in 2006 with good results, but stopped in 2010 due to nerve damage (MS) from it. Now getting good results with no-starch diet.

Top
#511512 - 06/26/15 01:08 PM Re: Low Birthweight/Childhood Infections / Predict AS [Re: MollyC1i]
arsimoun Offline
New_Member

Registered: 02/17/05
Posts: 21
Hmmm. 6.5 lbs. Premie born before me -- didn't make it. Older half brother. Younger brother, younger sister. Double mastoid infection at 18 months. Aseptic gram-negative infection at 17 (landed me in the hospital with IV antibiotics).

Adam Rodman

Top
#511517 - 06/27/15 09:32 AM Re: Low Birthweight/Childhood Infections / Predict AS [Re: arsimoun]
Sue22 Offline
Very_Addicted_to_AS_Kickin

Registered: 01/13/08
Posts: 21287
Loc: Upstate NY
I had a relatively low birthweight: 6 lbs? 6 lbs _ ounces? something like that. definitely not above that.

had german measles (rubella) before I can remember. my mom told me, told me it ruined their vacation. they were supposed to go down to florida and then i got sick.

i wonder if she'd remember how my GI was before and after that illness? I remember prune juice for constipation before I started school, but i wonder when that started?

Very interesting. Time will tell how all of this is related or not.

thanks molly. smile
_________________________


sue

Spondyloarthropathy, HLAB27 negative
Humira (still methylprednisone for flares, just not as often. Aleve if needed, rarely.)
LDN/zanaflex/flector patches over SI/ice
vits C, D. probiotics. hyaluronic acid. CoQ, Mg, Ca, K.
chiro
walk, bike
no dairy (casein sensitivity), limited eggs, limited yeast (bread)

Top
#511525 - 06/27/15 04:28 PM Re: Low Birthweight/Childhood Infections / Predict AS [Re: MollyC1i]
Pezami Offline
Third_Degree_AS_Kicker

Registered: 04/02/13
Posts: 278
I was a bonnie wee baby 9lbs
youngest of 5
normal amount of childhood illnesses but no hospitalizations.
I always had sprains and twisted ankles or such growing up
_________________________
Be kind, for everyone you meet is fighting a hard battle.
Plato

Top
#511841 - 07/26/15 10:01 AM Re: Low Birthweight/Childhood Infections / Predict AS [Re: MollyC1i]
arsimoun Offline
New_Member

Registered: 02/17/05
Posts: 21
Very interesting. 6.25 lbs at birth. Double mastoid infection at 12 months. Aseptic gram negative infection requiring hospitalization for two weeks of IV antibiotics at 17. Older half brother. Premature sibling before me that did not survive.

FWIW

Adam Rodman

Top
#511857 - 07/27/15 12:18 PM Re: Low Birthweight/Childhood Infections / Predict AS [Re: arsimoun]
Shirley Offline
Second_Degree_AS_Kicker

Registered: 08/23/12
Posts: 215
Loc: New Zealand
Interesting. I was just a couple of weeks early and 5 pounds 14. Did have some infections and ridges in adult teeth attributed to illness as a baby but no hospitalisations. I'm theoldest in my family.
_________________________
AS, IBS, reflux oesophagitis and dysphagia, PCOS/insulin resistance, asthma...
Currently managing my AS with humira, methotrexate, low starch diet and exercises. Also taking omeprazole, metformin etc.

Top
#511863 - 07/28/15 01:02 PM Re: Low Birthweight/Childhood Infections / Predict AS [Re: MollyC1i]
stevec Offline
Addicted_to_AS_Kickin

Registered: 09/05/01
Posts: 6221
Loc: Millstone NJ
I would ask is that a "chicken or egg study". Couldn't low birth weight, early childhood infections be manifestation of AS not elements of causation. I like the very random nature of the older sibling factor.

As for me. Above average birthwieght, middle of three children and has one mystery high grade undiagnosed fever befroe turning two. So except birthweight I guess I partially fit the parameters.
_________________________


L-R: Julianna, Jamie, Diane and Tonimarie

stevec-they also serve who stand and wait

Top
#511865 - 07/28/15 04:25 PM Re: Low Birthweight/Childhood Infections / Predict AS [Re: stevec]
Sue22 Offline
Very_Addicted_to_AS_Kickin

Registered: 01/13/08
Posts: 21287
Loc: Upstate NY
Originally Posted By stevec
I would ask is that a "chicken or egg study". Couldn't low birth weight, early childhood infections be manifestation of AS not elements of causation. I like the very random nature of the older sibling factor.

As for me. Above average birthwieght, middle of three children and has one mystery high grade undiagnosed fever befroe turning two. So except birthweight I guess I partially fit the parameters.


yes, correlation does not mean causation. smile
_________________________


sue

Spondyloarthropathy, HLAB27 negative
Humira (still methylprednisone for flares, just not as often. Aleve if needed, rarely.)
LDN/zanaflex/flector patches over SI/ice
vits C, D. probiotics. hyaluronic acid. CoQ, Mg, Ca, K.
chiro
walk, bike
no dairy (casein sensitivity), limited eggs, limited yeast (bread)

Top
Page 1 of 2 1 2 >

Who's Online
0 registered (), 97 Guests and 4 Spiders online.
Key: Admin, Global Mod, Mod
Recent Posts
branch retinal vein occlusion
by Magician
Yesterday at 11:41 PM
Mayo Clinic
by jackson
05/22/17 05:01 PM
Stop Remicade and manage with just NSAID's ?
by AsX
05/20/17 08:55 AM
Niacin
by jay_bharat
05/20/17 12:54 AM
NSD - Clarification
by jay_bharat
05/15/17 05:30 AM
Candida albicans
by Rayd
05/14/17 08:08 AM
No/Low Starch Diet Success/Failure Stories Ratio
by Robin_H
05/10/17 09:04 AM
(Views)Popular Topics
"FITNESS" TEAM! - All Physical Activity & Sports 30,720,423
hmmm 1,569,292
Has anyone had Pedicle subtraction Osteotomy ? 1,358,205
What to do about healthcare? Can it be fixed? 867,849
User names revisited 772,242
Medicinal Marijuana 681,785
A.S and beds, What do you find best? 668,623
OMG!!!! 633,051
No/Low Starch Diet Success Stories 470,366
THE STARCH CONTENT OF FOODS - THE LIST 401,334