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#498506 - 12/19/13 01:58 PM Chronic NSAID Use and Renal Decline
MollyC1i Offline

Registered: 01/21/04
Posts: 9783
Loc: Brittany, France (since Nov 08...

 Clinical and epidemiological research
Chronic NSAID use and long-term decline of renal function in a prospective rheumatoid arthritis cohort studyBurkhard Möller, Menno Pruijm, Sabine Adler, Almut Scherer, Peter M Villiger, Axel Finckh, on behalf of the Swiss Clinical Quality Management in Rheumatic Diseases (SCQM) Foundation, CH-8048 Zurich, Switzerland

(...) "In a multivariate Cox regression analysis adjusted for significant confounders age, sex, body mass index, arterial hypertension, heart disease and for other insignificant factors, NSAIDs were an independent predictor for accelerated renal function decline only in patients with advanced baseline renal impairment (eGFRCG <30&#8197;mL/min). Analyses with secondary outcomes and sensitivity analyses confirmed these results.

Conclusions NSAIDs had no negative impact on renal function estimates but in patients with advanced renal impairment."

MollyC1i - Riding OutAS

#501271 - 03/09/14 11:18 PM Re: Chronic NSAID Use and Renal Decline [Re: MollyC1i]
EricaK Offline

Registered: 06/23/10
Posts: 3800
Loc: Colorado, USA
Good info here Molly! I lasted 40 years on nsaids, my sister's both lasted about 35 years each. Lucky for me my kidneys are still great. Not so for one sis. I'm so glad we have you here!
ANA+ RF+ Rh- HLAB27+
Dx JRA 1967, GAD 1997, AS 2009, HMs 2010, CPS 2013
pulmonary edema w/ NSAIDS 2009

Movin' it so I don't lose it!

#503386 - 05/13/14 02:23 PM Re: Chronic NSAID Use and Renal Decline [Re: EricaK]
jpinperth Offline

Registered: 12/01/03
Posts: 1368
Loc: Canada, Ottawa

I took NSaids for 25 years and had to stop because of Gi issues. I am fortunate I have had no renal failure from them.


#503911 - 06/04/14 05:01 AM Re: Chronic NSAID Use and Renal Decline [Re: MollyC1i]
ron50 Offline

Registered: 06/02/14
Posts: 53
Loc: nambour,Queensland,Australia
I was on Naprosyn sr200 for around 25 years. Even with the help of zantac and cimetidine I suffered numerous bouts of peptic and duodenal ulcers. About ten years ago my doc put me onto somac. The doc who removed my gallbladder did an endoscopy and then doubled my dose of somac. All those years of nsaids and the fleet prep for ten colonoscopies and or an unknown auto immne disease and maybe even perhaps the eighteen months I spent on 75mg daily of prednisone and three years off and on of injecting methotrexate and did I mention the 48 sessions of 5fu and levamisole chemo for colon cancer. Well it means my kidneys are toast. I've had three biopsies for no diagnoses. I lose up to 7 grams a day of protein thru my kidneys ie. nephrotic syndrome. I take cyclosporine twice a day to keep out of dialysis.I have survived an aggressive stage3c colon cancer for nearly sixteen years but there is no doubt about it we are the sum total of every hit we ever took. It irks me that my AS was only diagnosed by accident but was never acted upon by my rheumatologist. He said it was not his business I should look for an orthopaedic specialist. I was never given any info about AS and did not know how bad it could be..I now know how painful it can be.. Ron.

Edited by ron50 (06/04/14 05:03 AM)


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