banners
Kickas Main Page | Rights and Responsibilities | Donate to Kickas
Kickas Links
·HOME
·Forums Main Index
·Register!
MEDICAL CENTRE
·Medicine Contract
·AS Patient Guidebook
·Pain Map
·Disease Modification
·Ask your doctor
·AS and RA Papers
·AS Acronyms
DIET CENTRE
·London AS Diet
·Molecular Mimicry
·AS Dietary Primer
·AS Food Guide
SUPPORT CENTRE
·In Memorium
·KickAS Stories
·KickAS Banners
·Donations
Forum Stats
12,685 Registered Members
28 Forums
43,344 Topics
515,691 Posts

Most users ever online: 1,568 @ 06/29/16 03:25 PM
Newest Members
Kells, HappySwede, ClearBlueSky, asumom, JJBT
12685 Registered Users
KickAs Team
Administrator/owner:
John (Dragonslayer)
Administrator:
Melinda (mig)
WebAdmin:
Timo (Timo)
Administrator:
Brad (wolverinefan)

Moderators:
- Tim (Dotyisle)
- Chelsea (Kiwi)
- Megan (Megan)
- Wendy (WendyR)
- John (Cheerful)
- Chris (fyrfytr187)

QR Code
If you want to use this QR code (Quick Response code) just save the image and paste it where you want. You can even print it and use it that way. Coffee cups, T-Shirts etc would all be good for the QR code.
Topic Options
#497875 - 11/29/13 04:53 PM RA - Impact of Disease Activity
MollyC1i Offline
Very_Addicted_to_AS_Kickin

Registered: 01/21/04
Posts: 9712
Loc: Brittany, France (since Nov 08...
http://ard.bmj.com/content/early/2013/11/29/annrheumdis-2013-204021.full#sec-12

Ann Rheum Dis doi:10.1136/annrheumdis-2013-204021
Clinical and epidemiological research
Extended report

Mortality in rheumatoid arthritis: the impact of disease activity, treatment with glucocorticoids, TNFα inhibitors and rituximab
Open Access

Annals of the Rheumatic Diseases
Abstract
Objectives To investigate the impact of disease activity, the course of the disease, its treatment over time, comorbidities and traditional risk factors on survival.

Methods Data of the German biologics register RABBIT were used. Cox regression was applied to investigate the impact of time-varying covariates (disease activity as measured by the DAS28, functional capacity, treatment with glucocorticoids, biologic or synthetic disease modifying antirheumatic drugs (DMARDs)) on mortality after adjustment for age, sex, comorbid conditions and smoking.

Results During 31&#8197;378 patient-years of follow-up, 463 of 8908 patients died (standardised mortality ratio: 1.49 (95% CI 1.36 to 1.63)). Patients with persistent, highly active disease (mean DAS28&#8201;&#8201;>&#8201;5.1) had a significantly higher mortality risk (adjusted HR (HRadj)=2.43; (95% CI 1.64 to 3.61)) than patients with persistently low disease activity (mean DAS28&#8201;<&#8201;3.2). Poor function and treatment with glucocorticoids >&#8197;5&#8197;mg/d was significantly associated with an increased mortality, independent of disease activity. Significantly lower mortality was observed in patients treated with tumour necrosis factor &#945; (TNF&#945;) inhibitors (HRadj=0.64 (95% CI 0.50 to 0.81), rituximab (HRadj=0.57 (95% CI 0.39 to 0.84), or other biologics (HRadj=0.64 (95% CI 0.42 to 0.99), compared to those receiving methotrexate. To account for treatment termination in patients at risk, an HRadj for patients ever exposed to TNF&#945; inhibitors or rituximab was calculated. This resulted in an HRadj of 0.77 (95% CI 0.60 to 0.97).

Conclusions Patients with long-standing high disease activity are at substantially increased risk of mortality. Effective control of disease activity decreases mortality. TNF&#945; inhibitors and rituximab seem to be superior to conventional DMARDs in reducing this risk.

cat

Full report available - open access.
_________________________
MollyC1i - Riding OutAS

Top
#497891 - 11/29/13 08:48 PM Re: RA - Impact of Disease Activity [Re: MollyC1i]
Shirley Offline
Second_Degree_AS_Kicker

Registered: 08/23/12
Posts: 215
Loc: New Zealand
Thanks Molly that's really interesting.

Hopefully one day they'll do a similar study for AS but I can't think of any reason why the findings wouldn't apply to that too. I do worry a bit about the long term elevation in my CRP levels, although treatment has reduced it quite a bit.
_________________________
AS, IBS, reflux oesophagitis and dysphagia, PCOS/insulin resistance, asthma...
Currently managing my AS with humira, methotrexate, low starch diet and exercises. Also taking omeprazole, metformin etc.

Top

Moderator:  WendyR 
Who's Online
1 registered (Arindam), 126 Guests and 2 Spiders online.
Key: Admin, Global Mod, Mod
Recent Posts
Headaches from Humira
by baileyo
08/15/17 06:43 PM
Dr. Reveille
by Tnate
08/11/17 12:27 AM
Various questions, and about Candida
by kj243
08/10/17 02:10 PM
updating account
by Possi
08/10/17 12:41 PM
Hello!!!
by Possi
08/10/17 12:39 PM
Ubiquitous Steroid Use Unwitting Cause for Glaucom
by MollyC1i
08/09/17 04:30 AM
Mottling skin on arms and legs
by Lon
08/07/17 03:42 PM
(Views)Popular Topics
"FITNESS" TEAM! - All Physical Activity & Sports 34,009,547
hmmm 1,692,081
Has anyone had Pedicle subtraction Osteotomy ? 1,451,422
What to do about healthcare? Can it be fixed? 939,220
User names revisited 814,678
Medicinal Marijuana 725,962
A.S and beds, What do you find best? 721,673
OMG!!!! 678,282
No/Low Starch Diet Success Stories 499,768
THE STARCH CONTENT OF FOODS - THE LIST 413,751