banners
Kickas Main Page | Rights and Responsibilities | Donate to Kickas
Kickas Links
·HOME
·Forums Main Index
·Register!
MEDICAL CENTRE
·Medicine Contract
·AS Patient Guidebook
·Pain Map
·Disease Modification
·Ask your doctor
·AS and RA Papers
·AS Acronyms
DIET CENTRE
·London AS Diet
·Molecular Mimicry
·AS Dietary Primer
·AS Food Guide
SUPPORT CENTRE
·In Memorium
·KickAS Stories
·KickAS Banners
·Donations
Forum Stats
13,093 Registered Members
28 Forums
43,543 Topics
517,216 Posts

Most users ever online: 1,568 @ 06/29/16 03:25 PM
Newest Members
Kipp, LivAustralia, Skip24, Emacdona, CHANDRAMOHAN
13093 Registered Users
KickAs Team
Administrator/owner:
John (Dragonslayer)
Administrator:
Melinda (mig)
WebAdmin:
Timo (Timo)
Administrator:
Brad (wolverinefan)

Moderators:
- Tim (Dotyisle)
- Chelsea (Kiwi)
- Megan (Megan)
- Wendy (WendyR)
- John (Cheerful)
- Chris (fyrfytr187)

QR Code
If you want to use this QR code (Quick Response code) just save the image and paste it where you want. You can even print it and use it that way. Coffee cups, T-Shirts etc would all be good for the QR code.
Topic Options
#497875 - 11/29/13 04:53 PM RA - Impact of Disease Activity
MollyC1i Offline
Very_Addicted_to_AS_Kickin

Registered: 01/21/04
Posts: 9783
Loc: Brittany, France (since Nov 08...
http://ard.bmj.com/content/early/2013/11/29/annrheumdis-2013-204021.full#sec-12

Ann Rheum Dis doi:10.1136/annrheumdis-2013-204021
Clinical and epidemiological research
Extended report

Mortality in rheumatoid arthritis: the impact of disease activity, treatment with glucocorticoids, TNFα inhibitors and rituximab
Open Access

Annals of the Rheumatic Diseases
Abstract
Objectives To investigate the impact of disease activity, the course of the disease, its treatment over time, comorbidities and traditional risk factors on survival.

Methods Data of the German biologics register RABBIT were used. Cox regression was applied to investigate the impact of time-varying covariates (disease activity as measured by the DAS28, functional capacity, treatment with glucocorticoids, biologic or synthetic disease modifying antirheumatic drugs (DMARDs)) on mortality after adjustment for age, sex, comorbid conditions and smoking.

Results During 31&#8197;378 patient-years of follow-up, 463 of 8908 patients died (standardised mortality ratio: 1.49 (95% CI 1.36 to 1.63)). Patients with persistent, highly active disease (mean DAS28&#8201;&#8201;>&#8201;5.1) had a significantly higher mortality risk (adjusted HR (HRadj)=2.43; (95% CI 1.64 to 3.61)) than patients with persistently low disease activity (mean DAS28&#8201;<&#8201;3.2). Poor function and treatment with glucocorticoids >&#8197;5&#8197;mg/d was significantly associated with an increased mortality, independent of disease activity. Significantly lower mortality was observed in patients treated with tumour necrosis factor &#945; (TNF&#945;) inhibitors (HRadj=0.64 (95% CI 0.50 to 0.81), rituximab (HRadj=0.57 (95% CI 0.39 to 0.84), or other biologics (HRadj=0.64 (95% CI 0.42 to 0.99), compared to those receiving methotrexate. To account for treatment termination in patients at risk, an HRadj for patients ever exposed to TNF&#945; inhibitors or rituximab was calculated. This resulted in an HRadj of 0.77 (95% CI 0.60 to 0.97).

Conclusions Patients with long-standing high disease activity are at substantially increased risk of mortality. Effective control of disease activity decreases mortality. TNF&#945; inhibitors and rituximab seem to be superior to conventional DMARDs in reducing this risk.

cat

Full report available - open access.
_________________________
MollyC1i - Riding OutAS

Top
#497891 - 11/29/13 08:48 PM Re: RA - Impact of Disease Activity [Re: MollyC1i]
Shirley Offline
Second_Degree_AS_Kicker

Registered: 08/23/12
Posts: 215
Loc: New Zealand
Thanks Molly that's really interesting.

Hopefully one day they'll do a similar study for AS but I can't think of any reason why the findings wouldn't apply to that too. I do worry a bit about the long term elevation in my CRP levels, although treatment has reduced it quite a bit.
_________________________
AS, IBS, reflux oesophagitis and dysphagia, PCOS/insulin resistance, asthma...
Currently managing my AS with humira, methotrexate, low starch diet and exercises. Also taking omeprazole, metformin etc.

Top

Moderator:  WendyR 
Who's Online
1 registered (Frederick), 96 Guests and 2 Spiders online.
Key: Admin, Global Mod, Mod
Recent Posts
Skin that burns and is sensitive to pressure
by Robin_H
09/22/18 10:57 PM
How I cured my AS (continued)
by davidchen
09/06/18 02:46 AM
vagus nerve stimulation, using ear clips with tens
by j87x
09/04/18 02:30 PM
ME DIAGNOSTICARON HACE 1 MES NECESITO APOYO
by yovafranc
08/30/18 05:45 PM
probiotic ideas, sbi protect, and prescript assist
by kj243
08/29/18 05:25 PM
3rd Spinal Correction Surgery Within Last 14 Month
by AJ_FUSED
08/25/18 08:10 AM
Teeth/Dental Problems
by Amber_UK
08/23/18 03:49 AM
(Views)Popular Topics
"FITNESS" TEAM! - All Physical Activity & Sports 39,535,639
hmmm 2,109,460
Has anyone had Pedicle subtraction Osteotomy ? 1,757,669
What to do about healthcare? Can it be fixed? 1,178,952
User names revisited 958,893
Medicinal Marijuana 884,054
A.S and beds, What do you find best? 872,821
OMG!!!! 825,101
No/Low Starch Diet Success Stories 628,482
THE STARCH CONTENT OF FOODS - THE LIST 459,722