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#484053 - 02/23/13 12:44 PM Does low GFR mean kidney disease?
Dizzydi Offline
New_Member

Registered: 02/22/13
Posts: 4
Hi there, I am a newbie,

Also thank you for giving me the opportinity to join a wonderful helpful site, much appreciated.

What I want to know it if possible please, if low gfr always mean kidney disease? or could it mean another health condition that can cause the functioning of the GFR to drop?

Thank you in advance?

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#484054 - 02/23/13 12:59 PM Re: Does low GFR mean kidney disease? [Re: Dizzydi]
Possi Offline
Addicted_to_AS_Kickin

Registered: 11/13/02
Posts: 6737
Loc: Oklahoma where the wind comes...
Welcome Dizzydi,

This is a wonderful site with great friendly informed people.
I am not going to try to answer your question. :o) Just want to welcome you.

Come back often.

Possi
_________________________


Possi
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WALK IF YOU HAVE TO,
CRAWL IF YOU MUST,
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#484055 - 02/23/13 01:06 PM Re: Does low GFR mean kidney disease? [Re: Possi]
Dizzydi Offline
New_Member

Registered: 02/22/13
Posts: 4
Hi Possi

And thank you. It's a wonderful site. x

I am from the UK ;-)


Edited by Dizzydi (02/23/13 01:07 PM)

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#484061 - 02/23/13 02:13 PM Re: Does low GFR mean kidney disease? [Re: Dizzydi]
cemc Offline
Captain_AS_Kicker

Registered: 01/25/10
Posts: 1971
Loc: UK
How low is your eGFR? Mine hovers between 55 and 65, which is a bit odd as it usually is meant to just do a slow decrease rather than go up and down like mine does. My doctor isn't concerned right now because I don't have obvious protein in my urine. Chronic kidney disease (CKD) is actually very common. It would seem that once it gets to 60 or below in the Uk they start to monitor you with regular blood tests (though mine are only once a year), and if it drops more than 5 points a year they would look at it more seriously. Also if you show protein regularly in your urine. You don't even get referred to renal specialists here unless you have a specific disease that might be affecting your kidneys (and I think lupus is probably the only rheumatology one they consider significant) or eGFR gets down to about 45 I think.

Ask your GP about it though, and ask how often they are going to monitor it, and get them to check your blood pressure.

I think the answer to your question "does a low eGFR always mean kidney disease" is yes, but that doesn't mean its significant, or that there is a definite reason for it, or that it needs treating, though once its noticed your GP should regularly check things like blood pressure etc and monitor it.

Note that my answer comes from my experience in the UK, and you'd possibly get quite a different answer about investigations for CKD in the US or another country.

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#484067 - 02/23/13 04:01 PM Re: Does low GFR mean kidney disease? [Re: cemc]
Dizzydi Offline
New_Member

Registered: 02/22/13
Posts: 4
Originally Posted By: cemc
How low is your eGFR? Mine hovers between 55 and 65, which is a bit odd as it usually is meant to just do a slow decrease rather than go up and down like mine does. My doctor isn't concerned right now because I don't have obvious protein in my urine. Chronic kidney disease (CKD) is actually very common. It would seem that once it gets to 60 or below in the Uk they start to monitor you with regular blood tests (though mine are only once a year), and if it drops more than 5 points a year they would look at it more seriously. Also if you show protein regularly in your urine. You don't even get referred to renal specialists here unless you have a specific disease that might be affecting your kidneys (and I think lupus is probably the only rheumatology one they consider significant) or eGFR gets down to about 45 I think.

Ask your GP about it though, and ask how often they are going to monitor it, and get them to check your blood pressure.

I think the answer to your question "does a low eGFR always mean kidney disease" is yes, but that doesn't mean its significant, or that there is a definite reason for it, or that it needs treating, though once its noticed your GP should regularly check things like blood pressure etc and monitor it.

Note that my answer comes from my experience in the UK, and you'd possibly get quite a different answer about investigations for CKD in the US or another country.



Thank you for your input.
I am also in the UK.

The last 3 tests since last May 2012 - 52, then Nov 50, last week recorded at 51, this test was done last Monday 18th Feb 2013 was 51GFR, and my GP is referring me to a Nephrologist, although the list is rather long it can take up to about November before I get to see one.

I am 44 years old (white female), on meds for high bp for the last 10 years just over and recently for cholesterol.

My GP said that I will be checked 3 to 6 months to be kept monitored, but to keep my BP in control.

I have also cut out salts, and drink more water, as I was never much of a water drinker until recent.

Urine tests normal.


Edited by Dizzydi (02/23/13 04:02 PM)

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#484090 - 02/24/13 02:15 AM Re: Does low GFR mean kidney disease? [Re: Dizzydi]
rumble Offline
Supreme_AS_Kicker

Registered: 01/31/09
Posts: 4226
Loc: NE Oklahoma
It is tied to the creatinine measurement and your age/sex/race. Whatever affects your creatinine will affect your GFR. That's the short answer. Ask your doc if he/she can answer this question in light of YOUR creatinine. Here is some info from a good source. Keep this site bookmarked because it gives great information on many, many lab tests. (from your friendly neighborhood medical technologist)

eGFR information
_________________________
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#484096 - 02/24/13 07:05 AM Re: Does low GFR mean kidney disease? [Re: rumble]
Dizzydi Offline
New_Member

Registered: 02/22/13
Posts: 4
Hi Rumble and thank you.

Yes it is tied to creatinine measurement
With being new to this sort of thing as well, I find it confusing, but getting there I think.
There was some improvement on the creatinine last week but stil not enough.
I shall have to get hold of the information in front of me to see what is what, but was told my last reading of gfr was 51, a rise of 1% not a lot but better thsn decreasing I suppose.

Can kidney infections also affect creatnine levels, sorry for the questions.

Thank you.

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#484117 - 02/24/13 03:03 PM Re: Does low GFR mean kidney disease? [Re: Dizzydi]
cemc Offline
Captain_AS_Kicker

Registered: 01/25/10
Posts: 1971
Loc: UK
Glad you have been referred to a nephrologist, though sorry that the waiting list is long. I know I haven't got a show of being referred to anyone until my eGFR gets well below 50.

One thing that you could probably ask about, is if they are going to do a biopsy. If they do one, then make sure they know that you have AS, and ask them if they are going to check for and rule out amyloidosis. It requires special stains to look for it, and because its rare they might not think about it, but secondary amyloidosis is a recognised rare complication of uncontrolled inflammation. If you did happen to have secondary amyloidosis then its all the more important to get your inflammation under control, and once that happens there is a possibility your kidney function would even improve a bit. Amyloidosis also requires referral to the National Amyloidosis Centre in London for proper management. Just be aware if you google it, that the rather poor prognosis they talk about is for primary amyloidosis, not secondary. Secondary is much more controllable.

FWIW I am pretty convinced that my kidney function is related to inflammation - it actually got a whole lot better during the time I was taking regular NSAIDs and my inflammation wasn't too badly under control, then got worse again when I had to stop taking them. That doesn't exactly fit with the usual assumption that NSAIDs and pain meds can damage your kidneys.

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