Been on humira for 2 months now and have noticed no change. If anything, I have been on the decline for the last 5 months or so. Getting a bit frustrated with it all, was expecting to see much better results on humira. Maybe I am unresponsive but perhaps it will just take longer to work, I really don't know.

Another interesting thing that I have noticed is that I havn't had a cold, flu or any illness like that while being on humira. It's approaching winter over here and I've even been going to school in a t-shirt. I find it strange that I haven't caught anything.

Often it can take up to 6 months or even longer. Stick with it...I'm sure it will kick in soon

Don't give up too quickly as then you've lost your chance with it.

Sorry, no decrease in pain yet. It is great, however, you have not gotten sick. It sounds like your immune system may be very over reactive, even with the medicine. I am sure the medicine is slowing down your progression and in time, will help your pain too. We are here for you in the meantime.

Shari

Sorry you aren't seeing any results yet. I've been on Enbrel for 5 months and have only seen a bit of increase in stamina and a little decrease in morning stiffness. At the same time, more pain in hands, with a bit of swelling of fingers in morning. Feet are hurting worse than they were 2 months ago. And my PCP told me that the rash on my elbow (that has come and gone for about 6-7 yrs) is psoriasis. Maybe a new diagnosis of my inflammatory arthritis to PsA? Anyway, hope you get something good starting soon.

I haven't been sick on Enbrel yet, but on Remicade, I got a couple of sinus infections--nothing bad.

Hugs to you, seb. Hang on, it takes time. And it could be a mystery that can't be solved for a few more months. At that point, you can look back over 24 weeks and maybe see a pattern of symptoms that doesn't look like much right now at 8 weeks. Take notes for yourself each week...sort of a diary of how you feel. It's so hard to look back over a number of weeks and remember how you felt if you don't write it down somewhere.

From what I understand Humuria and many other biologics outside of Enbrel and Cimzia have to be used with methetraxate.

Sorry to hear you haven't noticed any positive effect yet.

Apart from the suggestion already made that you might need to stick with it for a few more months yet, I wonder if there has been an effect, but you just haven't noticed it. Its really easy to keep pushing ourselves until things get painful before stopping. If humira is actually doing something, then you might still be getting pain because you are actually doing a lot more than you used to and your activity "limit" has shifted. Can you check things like how stiff you used to be against now? how far you can bend over, etc. I haven't been on the anti-tnfs but I know with my last steroid injection it took a week for me to realise how much better things were, from how much more I was able to do - I still actually had fairly bad pain by the end of the day because I had pushed myself too far. If I'd just used my pain as an indicator I would have said there was no improvement when clearly there was.

Sometimes too the changes are so gentle that we are the last ones to actually notice the difference when other people see quite dramatic changes in us.