NSAIDs and Cardiovascular Risk Explained (May 2, 2012) -- After nearly 13 years of study and intense debate, a pair of new articles have confirmed exactly how a once-popular class of anti-inflammatory drugs leads to cardiovascular risk for people taking it
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Joining the dots - should have occuredd to me years ago, or at least to my doctors *various!!
Going back to 1991 and the 'real' start of this flaming AS monster: my first flare. Unable to get out of bed, Huge difficulty in dressing. Desperate pain. NSAIDs. OTC Paracetamol - knew what I could tolerate and what worked for *me. Then the achilles tendon problem (R.ankle) with the heel bone spur - could hardly walk. Then the right knee - blew up. Collapsing on me (breaking forward) especially dangerous whilst crossing the road! All the time on Paracetamol (must have been eating them!) and don't remember taking other pain killers.
No. Did not see a specialist excepting for one utterly crappy rheumy who wanted to inject cortisone into my heel...
For years had had low blood pressure. Would feel dizzy on getting up from a chair or from bed in the morning. Years of low B.P. (And when I had operations, they *always had to tip me up from the feet due to low BP - alarmingly low they told me).
OK. Now move forward. Year 2002. Second flare. Neck. Completely spasmed. Could not left head - had to use hand to 'lift' and could not turn neck. Was in agony. Lasted six months with residual pain for over a year - walking or any jerking was intolerable. More NSAIDs - this time prescription NSAIDs. Ibuprofen. Meloxicam - Oh, and a whole range of em (and still have - as kept - the packets, with still some tablets left over, and of course all date marked!)
Then, second flare. Neck, again. Then R.knee, again. Then R.elbow. Then L.shoulder. On yet more NSAIDs. Followed by surgery on shoulder X2, and elbow. More NSAIDs...
Then gut shredded to pieces. Plus, NSAIDs just not hacking it.
THEN - Hypertension. Massive spikes of hypertension. Crazy.
Then. Change to COX-2 inhibitors. (Celebrex, then Vioxx, then back to Celebrex). Phew. Worked like a dream for me. Bliss.
Then...more gut probs. Finally discovered all the polyps - Ha. Familial Adenomatous Polyps, FAP. Thanks. (Nice googly - curve ball in Americanese <VBG>)
More hypertension. Then a minor heart attack Dec 2007 - showed up on pre-op assessment.
Then found out about LDN here on KA. Started the LDN - with pain meds for any breakthrough pain.
Roll forward to 2011. Rheumy consultation and diagnostics discovered a CVA - think I can relate this to spring 2011 (horrible feeling - right weird).
Now. Interesting twist to all this. Go back and read that paper. See the note on NOs? OK. Vascular dysregulation, retina. NTG - no tension - glaucoma. Bingo. NTG is now considered a vascular dysregulation. A 'different' condition to POAG Glaucoma - that is, POAG = raised intraoptic pressures, over 20 IOP. (Mine are 8 - 12mmHg and 12 - 14mmHg - NO tension).
NSAIDs. Flaming NSAIDs directly leading to Gut problems.
NSAIDs - directly leading to Hypertension & (mild) heart attack
NSAIDs - directly leading to that CVA
NSAIDs - due to causing vascular dysregulation, directly leading to NTG
Then the doctors here labeling me as 'Non-compliant' - with erstwhile GP insisting I go on Arcoxia - for a flare: ribs, costo, knee - (this in spite of side effects warnings? Sheesh). Including a 'top' rheumatologist here in France who blatantly snarled at me that I was 'Non-compliant and should take the advice of my doctors, take the NSAIDs, that they would control my pain'! He outright *refused to acknowledge that I had a problem with NSAIDs...and this in spite of his OWN authored papers!! (Can't invent them over here - and certainly can't invent 'him' - not in a month, nor yet a year, of Sundays!)
OK guys. Back to that paper again. I have NOs that I can take, AAKG: Alpha Arginine KetoGlutarate. Got to get back on it. Can't do owt about the vision I 'have' lost (R.eye is pretty bad now) but will try and save what is left of the sight in the R.eye and pray the L.eye continues to hold out for me. Also, to get this flaming hypertension under better control (too reactive to the anti-hypertensive drugs): yes, we're still working on it - now on drug #10!
Will be copying this through to my cardiologist - think he will be most interested. Meantime, will try and get back to England to see my decent rheumatologist. (Find out what the hell IS going on with neck, rib cage, SIs, feet - and this vascular neuropathy - or whatever the devil it IS!)
But you can see what these NSAIDs can do to a person over a time period. That is 22 years slowly developing after some 15 years of NSAIDs plus latter years with COX2 inhibitor use. WARNING.
Hope this new line in drug can be developed soon.