New remission criteria for RA: ‘modern times’ in rheumatology—not a silent film, rather a 3D movieLennart T H Jacobsson, Merete Lund Hetland
http://ard.bmj.com/content/70/3/401.extract?etocIn this issue of Annals of the Rheumatic Diseases, preliminary new criteria for remission in patients with RA—another merit of the new times—are published by Felson et al. 8
This paper is also the result of an ACR-EULAR collaboration, underlining globalisation of the world of rheumatology. The old remission criteria were like silent films—with disease potentially progressing silently under a cover of remission that allowed substantial disease activity to be present. The new criteria are more like a 3D movie—requiring no or minimal activity based on three dimensions: clinician's (swollen and tender joint counts) and patient's (global health score) …
http://ard.bmj.com/content/70/3/401.extract?etocCriteria American College of Rheumatology/European League Against Rheumatism Provisional Definition of Remission in Rheumatoid Arthritis for Clinical Trials
David T Felson, Josef S Smolen, George Wells, Bin Zhang, Lilian H D van Tuyl, Julia Funovits, Daniel Aletaha, Cornelia F Allaart, Joan Bathon, Stefano Bombardieri, Peter Brooks, Andrew Brown, Marco Matucci-Cerinic, Hyon Choi, Bernard Combe, Maarten de Wit, Maxime Dougados, Paul Emery, Daniel Furst, Juan Gomez-Reino, Gillian Hawker, Edward Keystone, Dinesh Khanna, John Kirwan, Tore K. Kvien, Robert Landewé, Joachim Listing, Kaleb Michaud, Emilio Martin-Mola, Pamela Montie, Theodore Pincus, Pamela Richards, Jeffrey N Siegel, Lee S Simon, Tuulikki Sokka, Vibeke Strand, Peter Tugwell, Alan Tyndall, Desirée van der Heijde, Suzan Verstappen, Barbar a White, Frederick Wolfe, Angela Zink, Maarten Boers
http://ard.bmj.com/cgi/content/abstract/70/3/404?etocConclusion We propose two new definitions of remission, both of which can be uniformly applied and widely used in RA clinical trials. The authors recommend that one of these be selected as an outcome measure in each trial and that the results on both be reported for each trial.
Recommendations EULAR recommendations for vaccination in adult patients with autoimmune inflammatory rheumatic diseasesS van Assen, N Agmon-Levin, O Elkayam, R Cervera, M F Doran, M Dougados, P Emery, P Geborek, J P A Ioannidis, D R W Jayne, C G M Kallenberg, U Müller-Ladner, Y Shoenfeld, L Stojanovich, G Valesini, N M Wulffraat, M Bijl
http://ard.bmj.com/content/70/3/414.abstract?etocConclusion Recommendations for vaccination in patients with AIIRD based on the currently available evidence and expert opinion were formulated. More research is needed, particularly regarding the incidence of vaccine-preventable infectious diseases and the safety of vaccination in patients with AIIRD.
Evaluating antirheumatic treatments using synovial biopsy: a recommendation for standardisation to be used in clinical trialsMarleen G H van de Sande, Danielle M Gerlag, Beatrijs M Lodde, Lisa G M van Baarsen, Stefano Alivernini, Veronica Codullo, Ioana Felea, Elsa Vieira-Sousa, Ursula Fearon, Richard Reece, Carlomaurizio Montecucco, Douglas J Veale, Costantino Pitzalis, Paul Emery, Lars Klareskog, Iain B McInnes, Paul P Tak
http://ard.bmj.com/content/70/3/423.abstract?etocAbstractInflammation of synovium is one of the hallmarks of rheumatoid arthritis (RA). Analysis of synovial tissue has increased our understanding of RA pathogenesis, aided in identifying potential therapeutic targets and has been used in the response and mechanistic evaluation of antirheumatic treatments. In addition, studies are ongoing, aimed at the identification of diagnostic and prognostic biomarkers in the synovium. This paper outlines the currently used procedures for sampling and processing of synovial tissue, and presents a standardised recommendation to support multicentre translational research.
Clinical and epidemiological research MRI in early rheumatoid arthritis: synovitis and bone marrow oedema are independent predictors of subsequent radiographic progressionPernille Bøyesen, Espen A Haavardsholm, Mikkel Østergaard, Désirée van der Heijde, Sølve Sesseng, Tore K Kvien
http://ard.bmj.com/content/70/3/428.abstract?etocConclusions Both baseline and 1-year cumulative measures of MRI synovitis and bone marrow oedema independently predicted 3-year radiographic progression. These results confirm that MRI synovitis and MRI bone marrow oedema precede radiographic progression in patients with early RA.
Diagnostic accuracy of enthesis ultrasound in the diagnosis of early spondyloarthritisEugenio de Miguel, Santiago Muñoz-Fernández, Concepción Castillo, Tatiana Cobo-Ibáñez, Emilio Martín-Mola
http://ard.bmj.com/content/70/3/428.abstract?etocConclusions Both baseline and 1-year cumulative measures of MRI synovitis and bone marrow oedema independently predicted 3-year radiographic progression. These results confirm that MRI synovitis and MRI bone marrow oedema precede radiographic progression in patients with early RA.
Development and preliminary validation of a paediatric-targeted MRI scoring system for the assessment of disease activity and damage in juvenile idiopathic arthritisClara Malattia, Maria Beatrice Damasio, Angela Pistorio, Maka Ioseliani, Iris Vilca, Maura Valle, Nicolino Ruperto, Stefania Viola, Antonella Buoncompagni, Gian Michele Magnano, Angelo Ravelli, Paolo Tomà, Alberto Martini
http://ard.bmj.com/content/70/3/440.abstract?etoc Definition of remission and relapse in polymyalgia rheumatica: data from a literature search compared with a Delphi-based expert consensusChristian Dejaco, Christina Duftner, Marco A Cimmino, Bhaskar Dasgupta, Carlo Salvarani, Cynthia S Crowson, Hilal Maradit-Kremers, Andrew Hutchings, Eric L Matteson, Michael Schirmer, and members of the International Work Group for PMR and GCA
Analysis of the influence of PTPN22 gene polymorphisms in systemic sclerosisLM Diaz-Gallo, P Gourh, J Broen, C Simeon, V Fonollosa, N Ortego-Centeno, S Agarwal, MC Vonk, M Coenen, G Riemekasten, N Hunzelmann, R Hesselstrand, FK Tan, JD Reveille, S Assassi, FJ García-Hernandez, P Carreira, MT Camps, A Fernandez-Nebro, P Garcia de la Peña, T Nearney, D Hilda, MA González-Gay, P Airo, L Beretta, R Scorza, A Herrick, J Worthington, A Pros, I Gómez-Gracia, L Trapiella, G Espinosa, I Castellvi, T Witte, F de Keyser, M Vanthuyne, MD Mayes, TRDJ Radstake, FC Arnett, J Martin, B Rueda
http://ard.bmj.com/content/70/3/454.abstract?etoc Study of the common genetic background for rheumatoid arthritis and systemic lupus erythematosusGisela Orozco, Steve Eyre, Anne Hinks, John Bowes, Ann W Morgan, Anthony G Wilson, Paul Wordsworth, Sophia Steer, Lynne Hocking, UKRAG consortium, Wendy Thomson, Jane Worthington, Anne Barton
http://ard.bmj.com/content/70/3/454.abstract?etoc Predictors of response to methotrexate in early DMARD naïve rheumatoid arthritis: results from the initial open-label phase of the SWEFOT trialSaedis Saevarsdottir, Helena Wallin, Maria Seddighzadeh, Sofia Ernestam, Pierre Geborek, Ingemar F Petersson, Johan Bratt, Ronald F van Vollenhoven, for the SWEFOT Trial Investigators Group
http://ard.bmj.com/content/70/3/469.abstract?etocConclusion Current smoking, female sex, longer symptom duration and younger age predict a worse response to MTX in patients with new-onset RA.
Preliminary criteria for the very early diagnosis of systemic sclerosis: results of a Delphi Consensus Study from EULAR Scleroderma Trials and Research GroupJ Avouac, J Fransen, UA Walker, V Riccieri, V Smith, C Muller, I Miniati, IH Tarner, S Bellando Randone, M Cutolo, Y Allanore, O Distler, G Valentini, L Czirjak, U Müller-Ladner, DE Furst, A Tyndall, M Matucci-Cerinic, EUSTAR Group
http://ard.bmj.com/content/70/3/476.abstract?etoc Lipid paradox in rheumatoid arthritis: the impact of serum lipid measures and systemic inflammation on the risk of cardiovascular diseaseElena Myasoedova, Cynthia S Crowson, Hilal Maradit Kremers, Veronique L Roger, Patrick D Fitz-Gibbon, Terry M Therneau, Sherine E Gabriel
http://ard.bmj.com/content/70/3/482.abstract?etocConclusion Inflammatory measures (particularly, ESR) are significantly associated with the risk of CVD in RA. Lipids may have paradoxical associations with the risk of CVD in RA, whereby lower TCh and LDL levels are associated with increased cardiovascular risk.
Long-term patient survival in ANCA-associated vasculitisOliver Flossmann, Annelies Berden, Kirsten de Groot, Chris Hagen, Lorraine Harper, Caroline Heijl, Peter Höglund, David Jayne, Raashid Luqmani, Alfred Mahr, Chetan Mukhtyar, Charles Pusey, Niels Rasmussen, Coen Stegeman, Michael Walsh, Kerstin Westman, for the European Vasculitis Study Group
http://ard.bmj.com/content/70/3/488.abstract?etocConclusion Patients with ANCA-associated vasculitis treated with conventional regimens are at increased risk of death compared with an age- and sex-matched population
Mutations in the autoinflammatory cryopyrin-associated periodic syndrome gene: epidemiological study and lessons from eight years of genetic analysis in FranceL Cuisset, I Jeru, B Dumont, A Fabre, E Cochet, J Le Bozec, M Delpech, S Amselem, I Touitou, and the French CAPS study group
http://ard.bmj.com/content/70/3/495.abstract?etocConclusions Although the number of NLRP3 test requests has doubled over the past 5 years, genetic screening has not contributed to enhanced detection of new index cases each year. There are two possible reasons for this: (i) no clinical prerequisite for genetic diagnosis and (ii) few new large families are now identified (unlike the initial study based on a selection by linkage). A set of initial clinical criteria have been drawn up which it is recommended should be fulfilled before a patient is tested: at least three recurrent bouts, age at disease onset < 20 years and elevated levels of C-reactive protein, especially in individuals with urticaria and moderate fever.
Utility of ultrasound joint counts in the prediction of rheumatoid arthritis in patients with very early synovitisAndrew Filer, Paola de Pablo, Gina Allen, Peter Nightingale, Alison Jordan, Paresh Jobanputra, Simon Bowman, Christopher D Buckley, Karim Raza
http://ard.bmj.com/content/70/3/500.abstract?etocConclusion In a longitudinal study, extended ultrasound joint evaluation significantly increased detection of joint involvement in all regions and outcome groups. Greyscale and power Doppler scanning of metacarpophalangeal joints, wrists and metatarsophalangeal joints provides the optimum minimal ultrasound data to improve on clinical predictive models for RA.
Smoking is a major preventable risk factor for rheumatoid arthritis: estimations of risks after various exposures to cigarette smokeHenrik Källberg, Bo Ding, Leonid Padyukov, Camilla Bengtsson, Johan Rönnelid, Lars Klareskog, Lars Alfredsson, EIRA Study Group
http://ard.bmj.com/content/70/3/512.abstract?etoc PADI4
polymorphism predisposes male smokers to rheumatoid arthritisYuta Kochi, Mohamed M Thabet, Akari Suzuki, Yukinori Okada, Nina A Daha, René E M Toes, Tom W J Huizinga, Keiko Myouzen, Michiaki Kubo, Ryo Yamada, Yusuke Nakamura, Kazuhiko Yamamoto
http://ard.bmj.com/content/70/3/512.abstract?etoc Generalisability of clinical registers used for drug safety and comparative effectiveness research: coverage of the Swedish Biologics RegisterM Neovius, JF Simard, A Sundström, L Jacobsson, P Geborek, T Saxne, N Feltelius, L Klareskog, J Askling, for the ARTIS Study Group
http://ard.bmj.com/content/70/3/516.abstract?etoc Increased cartilage turnover and circulating autoantibodies in different subsets before the clinical onset of rheumatoid arthritisCarl Turesson, Ulf Bergström, Lennart T H Jacobsson, Lennart Truedsson, Göran Berglund, Tore Saxne
Basic and translational research
Increased vascular penetration and nerve growth in the meniscus: a potential source of pain in osteoarthritis
Sadaf Ashraf, Helen Wibberley, Paul Ian Mapp, Roger Hill, Deborah Wilson, David Andrew Walsh
http://ard.bmj.com/content/70/3/520.abstract?etocConclusions Increased cartilage turnover, measured by COMP, and circulating RA-specific antibodies may be distinct processes in the preclinical phase of RA.
Involvement of functional autoantibodies against vascular receptors in systemic sclerosisGabriela Riemekasten, Aurélie Philippe, Melanie Näther, Torsten Slowinski, Dominik N Müller, Harald Heidecke, Marco Matucci-Cerinic, László Czirják, Ivo Lukitsch, Mike Becker, Angela Kill, Jacob M van Laar, Rusan Catar, Friedrich C Luft, Gerd R Burmester, Björn Hegner, Duska Dragun
http://ard.bmj.com/content/70/3/530.abstract?etocConclusions Functional autoimmunity directed at AT1R and ETAR is common in patients with SSc. AT1R and ETAR autoantibodies could contribute to disease pathogenesis and may serve as biomarkers for risk assessment of disease progression.
Changes in expression of membrane TNF, NF-B activation and neutrophil apoptosis during active and resolved inflammationHelen L Wright, Batsi Chikura, Roger C Bucknall, Robert J Moots, Steven W Edwards
http://ard.bmj.com/content/70/3/537.abstract?etocConclusions Neutrophils express elevated levels of TNF in RA and the transcription factor, NF-κB, a target of TNF, is activated. This mechanism could lead to a self-sustained inflammatory process. These data point to an important role of neutrophils in the abnormal TNF signalling pathways activated in RA and provide new evidence that neutrophils actively contribute to altered cytokine signalling in inflammatory diseases.
dsRNA activation of endothelin-1 and markers of vascular activation in endothelial cells and fibroblastsGiuseppina Farina, Michael York, Cindy Collins, Robert Lafyatis
http://ard.bmj.com/content/70/3/544.abstract?etocConclusion Together these data show that the dsRNA can regulate genes associated with vascular activation, as seen in SSc, that type I IFNs do not mediate these effects, and that EDN1 and ECE1 but not ICAM-1 activation is mediated by TLR3
Expanding the adipokine network in cartilage: identification and regulation of novel factors in human and murine chondrocytesJavier Conde, Rodolfo Gomez, Giuseppe Bianco, Morena Scotece, Pamela Lear, Carlos Dieguez, Juan Gomez-Reino, Francisca Lago, Oreste Gualillo
http://ard.bmj.com/content/70/3/551.abstract?etocConclusion Chemerin, LCN2 and SAA3 are implicated in chondrocyte pathophysiology, and regulated by other relevant factors that drive inflammatory process such as IL-1β, LPS and adipokines including leptin and adiponectin. It seems likely that JAK2, PI3K and MAP kinases are involved in mediating these responses.
EULAR have been extra busy busy - Hope I've picked up the gist of all these papers, if not...eyes! Gonna shut the ole PC down now.
