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#325276 - 02/02/09 06:38 AM NSAIDS - an your tum...
MollyC1i Offline
Very_Addicted_to_AS_Kickin

Registered: 01/21/04
Posts: 9833
Loc: Brittany, France (since Nov 08...
OK. This one is interesting -

http://www.mskreport.com/articles.cfm?articleID=3240
New OA Topicals Ease Pain, Protect Stomach

Yes, then read further, ho-hum!

"Adverse effects occurred in 85 out of 138 (61.6%) naproxen patients and 106 out of 207 (51.2%) IDEA-033 patients (51.2%). Discontinuation rates due to adverse effects were 18.1% in the naproxen group and 15.9% in the IDEA-033 group. Rates of severe adverse effects were 5.07% for naproxen and 4.35% for IDEA-033. Dr. Rother commented that most of the treatment-related AEs in the IDEA-033 patients were dermal irritations."

Over 18.1% & 15.9% dropping out due to adverse effects (over 65% & over 51% participants in the trial)- but were 'only' dermal irritations!' With 'severe' adverse effects (dermal irritations - only??) noted at 5.7% & 4.35% (high). Hmmmm, no wonder the oral doses of soooo many NSAIDS lead to ulcers, apalling gut damage etc etc.

At first thought: Hmmmmm. Looks good.' Don't think I'll be going there though...can't imagine 'dermal irritations' full blast, full time - or whatever...

Molly C (France)
Freezing outside, snow. An inside day, rummaging through cyberspace (hound aint 'amused' though!)
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MollyC1i - Riding OutAS

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#325277 - 02/02/09 06:54 AM Re: NSAIDS - an your tum... [Re: MollyC1i]
swim2lakes Offline
Active_Member

Registered: 12/30/08
Posts: 70
Loc: Fingerlakes, NY, USA

You wrote:
Hmmmm, no wonder the oral doses of soooo many NSAIDS lead to ulcers, apalling gut damage etc etc.

Actually,I think the skin reaction is from the DMSO.
about 25 years ago i tried some DMSO i got from a vet student on the SIJ area. DMSO not as a "carrier", for another med, but just on it's own. My memory is vague, but i think it did nothing for me other than burning my skin...

I like the idea of topicals, but where would one apply them when your whole body hurts.. dip me right in...
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#325278 - 02/02/09 07:04 AM Re: NSAIDS - an your tum... [Re: swim2lakes]
MollyC1i Offline
Very_Addicted_to_AS_Kickin

Registered: 01/21/04
Posts: 9833
Loc: Brittany, France (since Nov 08...
Quote: "I think the skin reaction is from the DMSO"

Good point Swim2. Should have read it with more 'patience'... (half attention on hound, who wants to go run around, but snow is nasty and wind is nasty and, and...what a crutch, eh? Poor hound. Shoot, I'd better go take her, but don't care to slip on the ice. And I *have to walk her to the lake as she gets car sick in a nano-second of sitting in car!)

N.B. (to self): Re-read article... 'smile' -

Molly C (France)
_________________________
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#325279 - 02/02/09 11:40 AM Re: NSAIDS - an your tum... [Re: MollyC1i]
PattyD1 Offline
Decorated_AS_Kicker

Registered: 09/26/08
Posts: 745
Loc: Colorado
When I was dx a year ago. My Rheummy was working with my gastro. They both agreed I can never do NSAIDS because of IBD. So in that way I was very lucky. If people do have to go on Nsaid, I would tell them to do them like you would do a steroid burst.

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